CN114222729 Amino acid transport inhibitors and uses thereof

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Application Number 202080056942.5

Application Date 12.06.2020

Publication Number 114222729

Publication Date 22.03.2022

Publication Kind A

IPC

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Applicants PANDERBITER UNIVERSITY
范德比尔特大学

Inventors MANNING, HAROLD, C.
H·C·曼宁
SCHULTE MICHAEL
M·舒尔特

Agents 永新专利商标代理有限公司 72002
永新专利商标代理有限公司 72002

Priority Data 62/860,677 12.06.2019 US

Title

(EN) Amino acid transport inhibitors and uses thereof

(ZH) 氨基酸转运抑制剂及其用途

Abstract

(EN) These compounds are glutamine transporter inhibitors, such as alanine, serine, cysteine transporter 2 (ASCT2) inhibitors. The glutamine transporter inhibitors are useful in the treatment of various diseases, disorders, or conditions, including cancer.

(ZH) 这些化合物是谷氨酰胺转运蛋白抑制剂，例如丙氨酸、丝氨酸、半胱氨酸转运蛋白2(ASCT2)抑制剂。谷氨酰胺转运蛋白抑制剂可用于治疗包括癌症的各种疾病、障碍或病症。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
209	Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02	condensed with one carbocyclic ring
04	Indoles; Hydrogenated indoles
30	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
42	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
307	Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77	ortho- or peri-condensed with carbocyclic rings or ring systems
78	Benzo furans; Hydrogenated benzo furans
82	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
84	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
85	attached in position 2

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
333	Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50	condensed with carbocyclic rings or ring systems
52	Benzo thiophenes; Hydrogenated benzo thiophenes
62	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
68	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
70	attached in position 2

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
235	Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02	condensed with carbocyclic rings or ring systems
04	Benzimidazoles; Hydrogenated benzimidazoles
24	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
263	Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52	condensed with carbocyclic rings or ring systems
54	Benzoxazoles; Hydrogenated benzoxazoles
58	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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1. CN114222729 - Amino acid transport inhibitors and uses thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40	having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403	condensed with carbocyclic rings, e.g. carbazole
404	Indoles, e.g. pindolol

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids
6876	Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883	for diseases caused by alterations of genetic material
6886	for cancer

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48	Biological material, e.g. blood, urine; Haemocytometers
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
574	for cancer