Processing

Please wait...

Settings

Settings

Goto Application

1. CN113950724 - METHOD OF IDENTIFYING A SURGICALLY OPERABLE TARGET ZONE IN AN EPILEPTIC PATIENT'S BRAIN

Office
China
Application Number 202080039224.7
Application Date 27.05.2020
Publication Number 113950724
Publication Date 18.01.2022
Publication Kind A
IPC
G16H 50/50
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
50for simulation or modelling of medical disorders
CPC
G16H 50/50
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
50for simulation or modelling of medical disorders
G16H 30/40
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
30ICT specially adapted for the handling or processing of medical images
40for processing medical images, e.g. editing
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 34/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
34Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
10Computer-aided planning, simulation or modelling of surgical operations
A61B 2034/105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
34Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
10Computer-aided planning, simulation or modelling of surgical operations
101Computer-aided simulation of surgical operations
105Modelling of the patient, e.g. for ligaments or bones
A61B 2034/107
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
34Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
10Computer-aided planning, simulation or modelling of surgical operations
107Visualisation of planned trajectories or target regions
Applicants UNIVERSITE D'AIX-MARSEILLE
艾克斯-马赛大学
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
法国国家健康和医学研究所
Inventors AN SORA
S·安
JIRSA VIKTOR
V·吉萨
Agents 中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001
Priority Data 19176827 27.05.2019 EP
Title
(EN) METHOD OF IDENTIFYING A SURGICALLY OPERABLE TARGET ZONE IN AN EPILEPTIC PATIENT'S BRAIN
(ZH) 在癫痫患者的脑中标识可通过手术操作的目标区的方法
Abstract
(EN) The invention relates to a method of identifying a potentially surgically operable target zone in an epileptic patient's brain. According to the invention, the method comprises the following steps: providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone; obtaining a patient's personalized computerized platform; deriving the potential target zones based on modularity analysis; evaluating the target zones' effectiveness by simulating epileptic seizures propagation in the personalized patient's computerized platform; evaluating the target zones' safety by simulating spatiotemporal brain activation patterns in a defined state condition and comparing the simulated spatiotemporal brain activation patterns obtained before removal of the target zone with the spatiotemporal brain activation patterns obtained after removal of the target zone; identifying the target zones which satisfy both effectiveness and safety evaluation criteria as potentially surgically operable target zones.
(ZH) 本发明涉及一种在癫痫患者的脑中标识潜在可通过手术操作的目标区的方法。根据本发明,所述方法包括以下步骤:提供计算机化平台,所述计算机化平台对灵长类动物脑的各个区以及所述区之间的连接性进行建模;提供致癫痫区的模型以及癫痫放电从癫痫区到传播区的传播的模型;获得患者的个性化计算机化平台;基于模块性分析来导出潜在目标区;通过在个性化的患者计算机化平台中对癫痫发作传播进行仿真来评价所述目标区的有效性;通过对所定义的状态条件下的时空脑激活模式进行仿真并且将在去除所述目标区之前获得的仿真时空脑激活模式与在去除所述目标区之后获得的时空脑激活模式进行比较,来评价所述目标区的安全性;将满足有效性和安全性评价标准两者的目标区标识为潜在可通过手术操作的目标区。