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1. BR112022013505 - COCRISTAIS DE 8-CLORO-N-(4- (TRIFLUOROMETOXI)FENIL)QUINOLIN-2-AMINA, MÉTODO PARA PREPARÁ-LOS, SAL FARMACEUTICAMENTE ACEITÁVEL DESTE, MÉTODO PARA PREPAR UM SAL FARMACEUTICAMENTE ACEITÁVEL DE ABX464 E COMPOSIÇÃO FARMACÊUTICA

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Brazil
Application Number EP2021052165
Application Date 29.01.2021
Publication Number 112022013505
Publication Date 13.09.2022
Publication Kind A2
IPC
C07D 215/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
C07D 215/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants ABIVAX
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
UNIVERSITE DE MONTPELLIER
INSTITUT CURIE
Inventors JÉRÔME MENEGOTTO
JÉRÔME DENIS
Agents BHERING ADVOGADOS ( NOME ANTERIOR BHERING ASSESSORIA S/C LTDA.)
Priority Data 20305090 31.01.2020 EP
Title
(PT) COCRISTAIS DE 8-CLORO-N-(4- (TRIFLUOROMETOXI)FENIL)QUINOLIN-2-AMINA, MÉTODO PARA PREPARÁ-LOS, SAL FARMACEUTICAMENTE ACEITÁVEL DESTE, MÉTODO PARA PREPAR UM SAL FARMACEUTICAMENTE ACEITÁVEL DE ABX464 E COMPOSIÇÃO FARMACÊUTICA
Abstract
(PT) COCRISTAIS DE 8-CLORO-N-(4-(TRIFLUOROMETOXI)FENIL)QUINOLIN-2-AMINA, MÉTODO PARA PREPARÁ-LOS, SAL FARMACEUTICAMENTE ACEITÁVEL DESTES, MÉTODO PARA PREPAR UM SAL FARMACEUTICAMENTE ACEITÁVEL DESTE, COMPOSIÇÃO FARMACÊUTICA E USO DESTES. A presente invenção diz respeito a cocristais e sais farmaceuticamente aceitáveis de 8-cloro-N-(4-(trifluorometoxi)fenil)quinolin-2-amina, composições farmacêuticas compreendendo-os, bem como seu uso como medicamentos e mais particularmente para uso na prevenção e/ou tratamento de doenças inflamatórias, doenças causadas por vírus e/ou câncer ou displasia. A presente invenção também se refere a métodos para a preparação dos referidos cocristais e dos referidos sais farmaceuticamente aceitáveis.
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