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1. BR112022003152 - compostos farmacêuticos

Office
Brazil
Application Number 112022003152
Application Date 20.08.2020
Publication Number 112022003152
Publication Date 17.05.2022
Publication Kind A2
IPC
C07D 487/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
A61K 31/5513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
55131,4-Benzodiazepines, e.g. diazepam ; or clozapine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants REVIRAL LIMITED
Inventors ANDREW JOSEPH WARNER
CRAIG ALEX AVERY
EDWARD JAMES COCHRANE
GEORGE STUART COCKERILL
JAMES GOOD
Agents TAVARES PROPRIEDADE INTELECTUAL LTDA. (ALT. DE TAVARES & COMPANHIA LTDA)
Priority Data 1911944.5 20.08.2019 GB
Title
(PT) compostos farmacêuticos
Abstract
(PT) compostos farmacêuticos. derivados de benzodiazepina de fórmula (i): em que: cada um de r1 e r2 é independentemente h ou halo; ou (i) t é n, z é c, a e c são ligações, e b e d estão ausentes; ou (ii) t é c, z é n, b e d são ligações, e a e c estão ausentes; cada um de r3 e r4 é independentemente halo, -or6, -nr6r7, -cor8, -c(o)or8, -con(r8)2 ou -r6; r5 é h ou halo; cada um de r6 e r7 é independentemente h ou um grupo selecionado de c1-c6 alquila, c3-c10 cicloalquila, c6-c10 arila, heterociclila de 4 a 10 membros e heteroarila de 4 a 10 membros, em que o grupo é não substituído ou substituído; r8 é h ou c1-c6 alquila, em que cada r8 é igual ou diferente quando dois estão presentes; n é 0 ou 1; e um de v, w, x e y é n ou ch e os outros três são ch; e os sais farmaceuticamente aceitáveis dos mesmos são inibidores de rsv e podem, portanto, ser usados para tratar ou prevenir uma infecção por rsv.
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