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1. WO2022140361 - GENETICALLY ENGINEERED LYMPHOCYTES FOR ADOPTIVE CELL THERAPY

Publication Number WO/2022/140361
Publication Date 30.06.2022
International Application No. PCT/US2021/064574
International Filing Date 21.12.2021
IPC
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C07K 14/61 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
61Growth hormone (GH) (Somatotropin)
C12N 5/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C07K 14/61
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
61Growth hormones [GH] (Somatotropin)
C12N 5/0006
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
0006Modification of the membrane of cells, e.g. cell decoration
C12N 5/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
Applicants
  • LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
  • CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS [CH]/[CH]
  • UNIVERSITY OF LAUSANNE [CH]/[CH]
Inventors
  • COUKOS, George
  • IRVING, Melita
  • CRIBIOLI, Elisabetta
Agents
  • MACLEOD, Janet, M.
  • CHEN, Joe
  • BARRISON, Flynn
  • FOIT, Linda
Priority Data
63/199,37622.12.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GENETICALLY ENGINEERED LYMPHOCYTES FOR ADOPTIVE CELL THERAPY
(FR) LYMPHOCYTES GÉNÉTIQUEMENT MODIFIÉS POUR THÉRAPIE CELLULAIRE ADOPTIVE
Abstract
(EN) Provided herein are lymphocytes suitable for use in adoptive cell transfer or adoptive cell therapy, as well as methods of making such lymphocytes and methods of using such lymphocytes in the treatment or cancer. Disclosed herein are lymphocytes that are genetically modified to express a glucose transporter and that are in contact with one or more cytokines. Also disclosed herein are lymphocytes that are genetically modified to express an amino acid transporter and an aminoacyl-tRNA synthetase.
(FR) L'invention concerne des lymphocytes pouvant être utilisés dans le transfert cellulaire adoptif ou la thérapie cellulaire adoptive, ainsi que des procédés de fabrication de ces lymphocytes et des procédés d'utilisation de ces lymphocytes dans le traitement ou le cancer. L'invention concerne des lymphocytes qui sont génétiquement modifiés pour exprimer un transporteur de glucose et qui sont en contact avec une ou plusieurs cytokines. L'invention concerne également des lymphocytes qui sont génétiquement modifiés pour exprimer un transporteur d'acides aminés et une aminoacyl-ARNt synthétase.
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