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1. WO2022139537 - POLYPEPTIDE SPECIFIC FOR MUCIN 1 AND USE THEREOF

Publication Number WO/2022/139537
Publication Date 30.06.2022
International Application No. PCT/KR2021/019790
International Filing Date 24.12.2021
IPC
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 14/705 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C12N 5/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
Applicants
  • 주식회사 엘지화학 LG CHEM, LTD. [KR]/[KR]
Inventors
  • 이지현 LEE, Ji Hyun
  • 이해연 LEE, Hae Youn
  • 최윤아 CHOI, Yoon Aa
  • 이대관 YI, Dae Gwan
  • 최정원 CHOI, Jungwon
  • 박아름 PARK, Areum
  • 정샘 JUNG, Saem
  • 송유림 SONG, Eu Rim
  • 나규봉 NA, Kyubong
  • 박민정 PARK, Min Jeong
  • 전은지 JEUN, Eun Ji
  • 최규홍 CHOE, Kyuhong
  • 이효주 YI, Hyoju
  • 양희정 YANG, Hee Jung
  • 장성웅 JANG, Sung Woong
Agents
  • 유미특허법인 YOU ME PATENT AND LAW FIRM
Priority Data
10-2020-018376824.12.2020KR
10-2021-013775715.10.2021KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) POLYPEPTIDE SPECIFIC FOR MUCIN 1 AND USE THEREOF
(FR) POLYPEPTIDE SPÉCIFIQUE DE LA MUCINE 1 ET UTILISATION ASSOCIÉE
(KO) 뮤신 1에 특이적인 폴리펩티드 및 이의 이용
Abstract
(EN) The present invention relates to a polypeptide binding to mucin 1, an isolated polynucleotide encoding same, a vector carrying the polynucleotide, and a cell including the vector. In addition, the present invention relates to a chimeric antigen receptor including the polypeptide binding to mucin 1, an isolated polynucleotide encoding the chimeric antigen receptor, a vector carrying the polynucleotide, an immune cell expressing the chimeric antigen receptor, a composition comprising same for treatment of cancer, and a method for treatment of cancer.
(FR) La présente invention concerne un polypeptide se liant à la mucine 1, un polynucléotide isolé le codant, un vecteur portant le polynucléotide, et une cellule comprenant le vecteur. De plus, la présente invention concerne un récepteur d'antigène chimérique comprenant le polypeptide se liant à la mucine 1, un polynucléotide isolé codant le récepteur d'antigène chimérique, un vecteur portant le polynucléotide, une cellule immunitaire exprimant le récepteur d'antigène chimérique une composition le comprenant pour le traitement du cancer, et un procédé de traitement du cancer.
(KO) 뮤신1(Mucin1)에 결합하는 폴리펩티드, 이를 코딩하는 단리된 폴리뉴클레오티드, 상기 폴리뉴클레오티드를 포함하는 벡터, 및 상기 벡터를 포함하는 세포에 관한 것이다. 또한, 뮤신1에 결합하는 폴리펩티드를 포함하는 키메라 항원 수용체, 상기 키메라 항원 수용체를 코딩하는 단리된 폴리뉴클레오티드, 상기 폴리뉴클레오티드를 포함하는 벡터, 상기 키메라 항원 수용체를 발현하는 면역 세포, 및 이들을 포함하는 암 치료용 조성물 및 치료 방법에 관한 것이다.
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