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1. WO2022134031 - CHEMICAL INDUCTION METHOD FOR PHOTORECEPTOR NEURON CELLS

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Publication Number WO/2022/134031
Publication Date 30.06.2022
International Application No. PCT/CN2020/139521
International Filing Date 25.12.2020
IPC
C12N 5/071 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
C12N 5/0793 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
079Neural cells
0793Neurons
A61K 35/30 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61P 17/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
CPC
A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
C12N 5/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
Applicants
  • 武汉睿健医药科技有限公司 IREGENE THERAPEUTICS LTD [CN]/[CN]
Inventors
  • 魏君 WEI, Jun
  • 蔡萌 CAI, Meng
  • 牛璐萌 NIU, Lumeng
  • 周佳 ZHOU, Jia
Agents
  • 中科专利商标代理有限责任公司 CHINA SCIENCE PATENT & TRADEMARK AGENT LTD.
Priority Data
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CHEMICAL INDUCTION METHOD FOR PHOTORECEPTOR NEURON CELLS
(FR) PROCÉDÉ D'INDUCTION CHIMIQUE POUR CELLULES NEURONALES PHOTORÉCEPTRICES
(ZH) 一种光感受器神经元细胞的化学诱导方法
front page image
Abstract
(EN) Provided is a pure chemical induction method for photoreceptor neuron cells. A group of small molecule inhibitors are added into a serum-free basic culture medium, and pluripotent stem cells are quickly converted into photoreceptor neuron cells. In the present invention, serum is not used, and chemical small molecules are used to replace retinol, eliminating the adverse factors of serum while ensuring the operation of visual circulation required by the development of photoreceptor neurons.
(FR) L'invention concerne un procédé d'induction chimique pure pour des cellules neuronales photoréceptrices. Un groupe d'inhibiteurs à petites molécules est ajouté dans un milieu de culture basique sans sérum, et des cellules souches pluripotentes sont rapidement converties en cellules neuronales photoréceptrices. Dans la présente invention, le sérum n'est pas utilisé, et des petites molécules chimiques sont utilisées pour remplacer le rétinol, éliminer les facteurs indésirables du sérum tout en assurant le fonctionnement de la circulation visuelle requise par le développement de neurones photorécepteurs.
(ZH) 提供了一种光感受器神经元细胞纯化学诱导方法，通过将一组小分子抑制剂添加至无血清基础培养基中，将多能干细胞快速转化为光感受器神经元细胞，本发明不使用血清，使用化学小分子替代视黄醇，保证了光感受器神经元发育所需要的视觉循环的运行的同时也排除了血清的不利因素。
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