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1. WO2021212183 - PRODUCTS OF MANUFACTURE AND METHODS FOR TREATING, AMELIORATING OR PREVENTING MICROBIAL INFECTIONS

Publication Number WO/2021/212183
Publication Date 28.10.2021
International Application No. PCT/AU2021/050369
International Filing Date 23.04.2021
IPC
A61K 31/4706 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/165 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/351 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
351not condensed with another ring
CPC
A61K 2300/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2300Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K 31/136
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
136having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/165
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/351
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
351not condensed with another ring
A61K 31/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
Applicants
  • CENTRE FOR DIGESTIVE DISEASES PTY LIMITED [AU]/[AU]
Inventors
  • BORODY, Thomas Julius
Agents
  • SPRUSON & FERGUSON
Priority Data
63/015,29424.04.2020US
63/019,81304.05.2020US
63/060,50803.08.2020US
63/109,24203.11.2020US
63/123,41609.12.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PRODUCTS OF MANUFACTURE AND METHODS FOR TREATING, AMELIORATING OR PREVENTING MICROBIAL INFECTIONS
(FR) PRODUITS DE FABRICATION ET PROCÉDÉS DE TRAITEMENT, D’AMÉLIORATION OU DE PRÉVENTION D’INFECTIONS MICROBIENNES
Abstract
(EN) Provided are products of manufacture fabricated or manufactured as medical devices such as an inhaler, an ionizer, an asthma "puffer-like" device, a nebulizer or a nasal spray device, a respirator or a ventilator, a warm or a hot air delivery device, and/or a CPAP (continuous positive air pressure) device or equivalent, for delivering one or a combination of medications or drugs, and optionally also warm or hot air, and optionally also ionized air. Said drug combinations include various combinations of antivirals, antiparasitics, antibacterials, and adjunct therapeutics, including at least one of Hydroxychloroquine, Chloroquine, Oseltamivir, Lopinavir, Ritonavir, Ribavirin, Favipiravir, Remdesivir, Azithromycin, Ivermectin, Doxycycline, and Opaganib or combinations thereof. Products of manufacture are used for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a microbial infection, such as bacterial and viral infections, including the common respiratory viruses such as influenza vims, respiratory syncytial vims, picornavims, parainfluenza vims, adenovims, rhinovims, human metapneumovims, hantavimses, enterovims, a coronavims infection, or a COVID-19 or a 2019-nCoV (SARS-CoV-2) infection, or an infection caused by a vims in the subfamily Orthocoronavirinae, or a vims in the family Coronaviridae, or a vims in the order Nidovirales. In alternative embodiments, products of manufacture as provided herein administer combinations, or cocktails, of a dmg or dmgs by inhalation, for example, by use of aerosol, mist, liquid or powder formulations for inhalation.
(FR) La présente invention concerne des produits de fabrication fabriqués ou conçus comme dispositifs médicaux tels qu’un inhalateur, un ionisateur, un dispositif par "pouffée" contre l'asthme, un dispositif de nébulisation ou de pulvérisation nasale, un respirateur ou un ventilateur, un dispositif de distribution d’air tiède ou chaud, et/ou un dispositif CPAP (à pression d’air positive continue) ou équivalent, pour administrer un médicament ou une médication ou une combinaison de médications ou de médicaments, et éventuellement également de l’air tiède ou chaud, et éventuellement également de l’air ionisé. Lesdites combinaisons de médicament comprennent diverses combinaisons d’antiviraux, d’antiparasitaires, d’antibactériens, et d’agents thérapeutiques complémentaires, comprenant au moins l’un parmi l’hydroxychloroquine, la chloroquine, l’oséltamivir, le lopinavir, le ritonavir, la ribavirine, le favipiravir, le remdesivir, l’azithromycine, l’ivermectine, la doxycycline, et l’opaganib ou leurs combinaisons. Les produits de fabrication sont utilisés dans le traitement, la prévention, l’amélioration, le ralentissement de la progression, la réduction de la gravité ou la prévention d’une infection microbienne, telle que des infections bactériennes et virales, comprenant les virus respiratoires ordinaires tels que les virus de la grippe, les virus syncytiaux respiratoires, les picornavirus, les virus parainfluenza, les adénovirus, les rhinovirus, les métapneumovirus humains, les hantavirus, les entérovirus, une infection par un coronavirus, ou une infection COVID-19 ou 2019-nCoV (SARS-CoV-2), ou une infection causée par un virus de la sous-famille des Orthocoronavirinae, ou un virus de la famille des Coronaviridae, ou un virus de l’ordre des Nidovirales. Dans des modes de réalisation alternatifs, les produits de fabrication tels que fournis ici administrent des combinaisons, ou des cocktails, d’un médicament ou de plusieurs médicaments par inhalation, par exemple, par l’utilisation d’aérosol, de brume, de formulations liquide ou en poudre pour l’inhalation.
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