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1. WO2022126236 - METHODS OF TREATING AND/OR PREVENTING ALZHEIMER'S DISEASE WITH R-CARVEDILOL

Publication Number WO/2022/126236
Publication Date 23.06.2022
International Application No. PCT/CA2021/051303
International Filing Date 17.09.2021
IPC
A61K 31/403 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 209/82 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
80- or -condensed
82Carbazoles; Hydrogenated carbazoles
Applicants
  • UTI LIMITED PARTNERSHIP [CA]/[CA]
Inventors
  • CHEN, Sui Rong Wayne
  • BACK, Thomas
  • YAO, Jinjing
Agents
  • MBM INTELLECTUAL PROPERTY LAW LLP
Priority Data
63/079,50817.09.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING AND/OR PREVENTING ALZHEIMER'S DISEASE WITH R-CARVEDILOL
(FR) MÉTHODES DE TRAITEMENT ET/OU DE PRÉVENTION DE LA MALADIE D'ALZHEIMER AVEC DU R-CARVEDILOL
Abstract
(EN) Methods of treating and/or preventing dysfunctions associated with Alzheimer's Disease such as memory loss, hippocampal long-term potentiation impairment, neuronal hyperactivity, and neuronal cell death using R-carvedilol, a metabolite thereof, and/or a salt thereof. Also described are related uses and pharmaceutical compositions.
(FR) L'invention concerne des méthodes de traitement et/ou de prévention de dysfonctionnements associés à la maladie d'Alzheimer tels que la perte de mémoire, l'hyperactivité neuronale et la mort cellulaire neuronale à l'aide de R-carvedilol, d'un métabolite de celui-ci, et/ou d'un sel de celui-ci. L'invention concerne également des utilisations et des compositions pharmaceutiques associées.
Latest bibliographic data on file with the International Bureau