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1. WO2021178574 - METHODS AND SYSTEMS FOR NITRIC OXIDE THERAPY FOR THE TREATMENT OR PREVENTION OF RESPIRATORY INFECTIONS

Publication Number WO/2021/178574
Publication Date 10.09.2021
International Application No. PCT/US2021/020725
International Filing Date 03.03.2021
IPC
A61B 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61K 33/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61P 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61B 5/14551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
14551for measuring blood gases
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
Applicants
  • KNOW BIO, LLC [US]/[US]
Inventors
  • STASKO, Nathan
  • KIMBLE, Kyle
Agents
  • NGUYEN, Quan
Priority Data
62/985,86905.03.2020US
62/990,83217.03.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND SYSTEMS FOR NITRIC OXIDE THERAPY FOR THE TREATMENT OR PREVENTION OF RESPIRATORY INFECTIONS
(FR) PROCÉDÉS ET SYSTÈMES DE THÉRAPIE À BASE D'OXYDE NITRIQUE POUR LE TRAITEMENT OU LA PRÉVENTION D'INFECTIONS RESPIRATOIRES
Abstract
(EN) Methods for the treatment of a. respiratory infection, for the prevention of worsening of symptoms associated, with the infection, and for reducing the lethality of the infection such as bin not limited to respiratory infections caused by a coronavirus. The present disclosure provides specific gaseous nitric oxide (NO) dosing regimens optionally paired with the monitoring of toxicology outcomes so as to enable the use of effective NO doses for treatment purposes. The present invention also discloses air circulation systems featuring NO for helping to prevent respiratory infections.
(FR) Sont ici décrits des procédés de traitement d'une infection respiratoire, de prévention de l'aggravation des symptômes associés à l'infection et de réduction de la létalité de l'infection, par exemple, mais non exclusivement des infections respiratoires provoquées par un coronavirus. La présente divulgation concerne des schémas posologiques spécifiques d'oxyde nitrique gazeux (NO) éventuellement associés à la surveillance des effets toxicologiques de façon à permettre l'utilisation de doses efficaces de NO à des fins de traitement. La présente invention concerne également des systèmes de circulation d'air comprenant du NO pour aider à prévenir des infections respiratoires.
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