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1. WO2022105787 - LONG ACTING BI-SPECIFIC T CELL ENGAGERS TARGETING CD3 AND CD47

Publication Number WO/2022/105787
Publication Date 27.05.2022
International Application No. PCT/CN2021/131181
International Filing Date 17.11.2021
IPC
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/32 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 39/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • SHENZHEN ENDURING BIOTECH, LTD. [CN]/[CN]
Inventors
  • WEN, Yu
  • LIU, Shumin
  • LYU, Weidong
  • WU, Dechun
Agents
  • LIU, SHEN & ASSOCIATES
Priority Data
PCT/CN2020/12934917.11.2020CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) LONG ACTING BI-SPECIFIC T CELL ENGAGERS TARGETING CD3 AND CD47
(FR) ACTIVATEURS DE LYMPHOCYTES T BISPÉCIFIQUES À ACTION PROLONGÉE CIBLANT CD3 ET CD47
Abstract
(EN) Provided are bispecific molecules and, in particular, long acting bispecific T cell engagers targeting CD3 and CD47 with improved efficacy, toxic profile and therapeutic window, and methods of making and using such long acting bispecific binding molecules.
(FR) L'invention concerne des molécules bispécifiques et, en particulier, des activateurs de lymphocytes T bispécifiques à action prolongée ciblant CD3 et CD47 ayant une efficacité, un profil toxique et une fenêtre thérapeutique améliorés, et des procédés de fabrication et d'utilisation de telles molécules de liaison bispécifiques à action prolongée.
Latest bibliographic data on file with the International Bureau