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1. WO2022100696 - MULTI-SPECIFIC BIOCONJUGATE LINKER AND SYNTHETIC METHOD THEREFOR

Publication Number WO/2022/100696
Publication Date 19.05.2022
International Application No. PCT/CN2021/130337
International Filing Date 12.11.2021
IPC
C07D 257/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
08Six-membered rings
C07D 225/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
225Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
04condensed with carbocyclic rings or ring systems
08condensed with two six-membered rings
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
A61K 39/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
A61K 31/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/4025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
44Antibodies bound to carriers
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 225/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
225Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
02not condensed with other rings
Applicants
  • 北京大学 PEKING UNIVERSITY [CN]/[CN]
Inventors
  • 陈鹏 CHEN, Peng
  • 林锋 LIN, Feng
  • 林坚 LIN, Jian
  • 张衡 ZHANG, Heng
Agents
  • 上海巅石知识产权代理事务所(普通合伙) SHANGHAI DIANSHI PARTNERS, P.C.
Priority Data
202011270000.513.11.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MULTI-SPECIFIC BIOCONJUGATE LINKER AND SYNTHETIC METHOD THEREFOR
(FR) LIEUR BIOCONJUGUÉ MULTI-SPÉCIFIQUE ET SON PROCÉDÉ DE SYNTHÈSE
(ZH) 多特异生物偶联连接臂及其合成方法
Abstract
(EN) Disclosed in the present application are a multi-specific bioconjugate linker and a synthetic method therefor, and specifically, a compound or a tautomer, a mesomer, a racemate, an enantiomer, or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. Also disclosed in the present application are a preparation method for the compound and use in tumor treatment.
(FR) La présente invention concerne un lieur bioconjugué multi-spécifique et son procédé de synthèse, et plus particulièrement, un composé ou un tautomère, un mésomère, un racémate, un énantiomère, ou un diastéréoisomère de celui-ci, ou un mélange de ceux-ci, ou un sel pharmaceutiquement acceptable de celui-ci. La présente invention concerne également un procédé de préparation du composé et une utilisation dans le traitement de tumeurs.
(ZH) 本申请公开了多特异生物偶联连接臂及其合成方法,具体公开了一种化合物或其互变异构体、内消旋体、外消旋体、对映异构体、非对映异构体,或其混合物形式,或其可药用的盐。本申请还公开了所述化合物的制备方法以及在肿瘤治疗中的用途。
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