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1. JP2022078203 - がんの免疫療法のためのNKG2D-IG融合タンパク質

Office
Japan
Application Number 2022033214
Application Date 04.03.2022
Publication Number 2022078203
Publication Date 24.05.2022
Publication Kind A
IPC
C07K 14/705
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07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 19/00
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07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 16/00
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07ORGANIC CHEMISTRY
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16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C12N 15/62
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C12N 15/13
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
C12N 15/12
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NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
CPC
C07K 14/70596
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07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
C07K 2319/30
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07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 38/178
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
178Lectin superfamily, e.g. selectins
A61K 38/2086
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
2086IL-13 to IL-16
C07K 14/7056
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
7056Lectin superfamily, e.g. CD23, CD72
Applicants デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
Inventors グレン・ドラノフ
ライアン・サリヴァン
マシュー・ヴァネマン
Agents 小林 浩
大森 規雄
日野 真美
Priority Data 62/255,016 13.11.2015 US
Title
(JA) がんの免疫療法のためのNKG2D-IG融合タンパク質
Abstract
(JA) 【課題】がんの免疫療法のための方法及び組成物を提供する。
【解決手段】本方法は、二量体NKG2D部分及びFc部分を含み、1つ又は複数のNKG2Dリガンドと結合するキメラ分子(例えば、融合タンパク質)の使用に関わる。いくつかの実施形態において、分子は、薬物部分(例えば、IL15/Ra部分)を更に含む。本発明の方法は、1つ又は複数のNKG2Dリガンドの異常な発現と関連するがんの処置のために有用である。
【選択図】図1