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1. CN114616244 - 特异性结合MAGE-A的抗原结合蛋白

Office
China
Application Number 202080055666.0
Application Date 31.07.2020
Publication Number 114616244
Publication Date 10.06.2022
Publication Kind A
IPC
C07K 16/28
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07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30
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07ORGANIC CHEMISTRY
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16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46
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16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C07K 19/00
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19Hybrid peptides
C12N 15/85
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
A61K 2039/505
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/5156
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5156expressing foreign proteins
C07K 16/2827
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07ORGANIC CHEMISTRY
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16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 16/30
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07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/468
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07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
C07K 2317/31
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2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
Applicants 伊玛提克斯生物技术有限公司
Inventors M·哈特
F·翁弗多尔本
S·邦克
D·毛勒
M·霍夫曼
G·普佐拉
S·优素福
C·瓦格纳
F·施沃贝尔
H·舒斯特
Agents 北京坤瑞律师事务所 11494
Priority Data 102019121007 02.08.2019 DE
62/882,131 02.08.2019 US
62/905,782 25.09.2019 US
Title
(ZH) 特异性结合MAGE-A的抗原结合蛋白
Abstract
(ZH) 本发明涉及特异性结合色素瘤相关抗原A(MAGE‑A)蛋白来源抗原的抗原结合蛋白。本发明特别提出了与MAGE‑A抗原肽特异性结合的抗原结合蛋白,所述MAGE‑A抗原肽包含SEQ ID NO:1或由SEQ ID NO:1组成且与主要组织相容性(MHC)蛋白形成复合体。特别地,本发明的抗原结合蛋白含有与所述MAGE‑A肽/MHC复合体特异性结合的新型改造T细胞受体(TCR)的互补决定区(CDR)。本发明的抗原结合蛋白可用于诊断、治疗和预防表达MAGE‑A的癌性疾病。还提出了编码本发明抗原结合蛋白的核酸、包含这些核酸的载体、表达抗原结合蛋白的重组细胞以及包含本发明抗原结合蛋白的药物组合物。