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1. WO2022138351 - TUMOR ANALYSIS SYSTEM

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Publication Number WO/2022/138351
Publication Date 30.06.2022
International Application No. PCT/JP2021/046157
International Filing Date 14.12.2021
IPC
C12M 1/34 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12Q 1/06 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
06Quantitative determination
C12Q 1/68 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/574 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12M 1/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
06Quantitative determination
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Applicants
  • 株式会社日立製作所 HITACHI, LTD. [JP]/[JP]
Inventors
  • 阿部　祥歩 ABE Sachiho
  • 安田　知弘 YASUDA Tomohiro
Agents
  • 特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES
Priority Data
2020-21635625.12.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) TUMOR ANALYSIS SYSTEM
(FR) SYSTÈME D'ANALYSE TUMORALE
(JA) 腫瘍解析システム
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Abstract
(EN) The present invention provides a system for analyzing the composition of cells in a tumor specimen. This system is characterized by including at least a calculation unit and is characterized in that at least one storage apparatus included in the system or connected to the system includes: the cell composition of a cancer clone obtained from cells included in the tumor specimen on the basis of gene mutation information; and the cell composition of normal cells obtained from cells included in the tumor specimen on the basis of a gene expression level, the system also being characterized in that the calculation unit executes: a step for adjusting the abundance ratios of each cell species, such that the total of the abundance ratios of each cell species is X (X is a constant of 0 to 1 inclusive and is a parameter designated by a user of the system) with respect to the cell composition of the cancer clone and the cell composition of the normal cells read out from the storage apparatus while taking it into consideration that normal cells are included in the unclassified cells out of the cell composition of the cancer clone; and a step for outputting the cell composition of the tumor specimen after the adjustment.
(FR) La présente invention concerne un système d'analyse de la composition de cellules dans un échantillon tumoral. Le système se caractérise par l'inclusion d'au moins une unité de calcul et en ce qu'au moins un appareil de stockage inclus dans le système ou connecté au système comprend les éléments suivants : la composition cellulaire d'un clone cancéreux obtenu à partir de cellules incluses dans l'échantillon tumoral sur la base d'informations sur les mutations génétiques; et la composition cellulaire de cellules normales obtenues à partir de cellules incluses dans l'échantillon tumoral sur la base d'un niveau d'expression génique. le système se caractérise également en ce que l'unité de calcul exécute les étapes suivantes : ajustement des ratios d'abondance de chaque espèce de cellule, de sorte que le total des ratios d'abondance de chaque espèce de cellule soit X (X est une constante de 0 à 1 inclus et est un paramètre défini par un utilisateur du système) par rapport à la composition cellulaire du clone cancéreux et à la composition cellulaire des cellules normales lues à partir de l'appareil de stockage tout en prenant en considération le fait que les cellules normales sont incluses dans les cellules non classées de la composition cellulaire du clone cancéreux; et fourniture de la composition cellulaire de l'échantillon de tumeur après l'ajustement.
(JA) 本発明は、腫瘍検体における細胞の組成を解析するためのシステムであって、少なくとも計算部を備え、前記システムが備える又は前記システムに接続された少なくとも１つの記憶装置が、腫瘍検体に含まれる細胞から遺伝子変異の情報をもとに取得されたがんクローンの細胞組成と、腫瘍検体に含まれる細胞から遺伝子発現量をもとに取得された通常細胞の細胞組成とを含み、前記計算部が、前記記憶装置から読み出した前記がんクローンの細胞組成及び通常細胞の細胞組成について、がんクローンの細胞組成のうち未分類の細胞に通常細胞が含まれることを考慮して、各細胞種の存在比の合計がＸ（Ｘは０以上１以下の定数であり、前記システムのユーザにより指定されるパラメータ）になるよう、各細胞種の存在比を調整するステップ、調整後の腫瘍検体の細胞組成を出力するステップを実行することを特徴とするシステムを提供する。
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