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1. WO2022007986 - 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE

Publication Number WO/2022/007986
Publication Date 13.01.2022
International Application No. PCT/CZ2021/050043
International Filing Date 15.04.2021
IPC
C07H 21/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/7084 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR, V. V. I. [CZ]/[CZ]
Inventors
  • BIRKUS, Gabriel
  • DEJMEK, Milan
  • NENCKA, Radim
  • OTAVA, Tomas
  • SALA, Michal
  • PAV, Ondrej
Agents
  • HARTVICHOVA, Katerina
Priority Data
20185156.510.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE
(FR) DINUCLÉOTIDES 3'3' CYCLIQUES COMPRENANT UN ALCÉNYLÈNE
Abstract
(EN) The present disclosure relates to 3'3' cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines. (Formula (J))
(FR) La présente divulgation concerne des dinucléotides phosphonates 3'3' cycliques de formule générale (J), leurs sels pharmaceutiquement acceptables, leur composition pharmaceutique et des combinaisons desdites substances et d'autres médicaments ou produits pharmaceutiques. L'invention concerne également l'utilisation desdits composés pour le traitement ou la prévention de maladies ou d'affections pouvant être modifiées par la modulation de la protéine STING, tels que le cancer ou des maladies virales, allergiques et inflammatoires. En outre, ces substances peuvent être utilisées comme adjuvants dans des vaccins. (Formule (J))
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