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1. WO2022007866 - FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF

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Publication Number WO/2022/007866
Publication Date 13.01.2022
International Application No. PCT/CN2021/105088
International Filing Date 08.07.2021
IPC
C07D 233/76 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Two oxygen atoms, e.g. hydantoin
76with substituted hydrocarbon radicals attached to the third ring carbon atom
C07D 233/72 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Two oxygen atoms, e.g. hydantoin
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4164 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
A61K 31/417 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
417Imidazole-alkylamines, e.g. histamine, phentolamine
A61P 19/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
04for non-specific disorders of the connective tissue
Applicants
  • 深圳信立泰药业股份有限公司 SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. [CN]/[CN]
Inventors
  • 吴俊军 WU, Junjun
  • 陆银锁 LU, Yinsuo
  • 肖瑛 XIAO, Ying
  • 吴建立 WU, Jianli
  • 洪泽新 HONG, Zexin
  • 段振芳 DUAN, Zhenfang
Priority Data
202010657928.209.07.2020CN
202110171283.607.02.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
(FR) DÉRIVÉ TRICYCLIQUE CONDENSÉ, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION PHARMACEUTIQUE
(ZH) 并三环类衍生物、其制备方法及其在医药上的应用
Abstract
(EN) A fused tricyclic derivative relating to the technical field of chemical drugs, a preparation method therefor, and a pharmaceutical application thereof. The fused tricyclic derivative is an inhibitor of aggrecanase-2 (ADAMTS-5). Also provided are a pharmaceutical composition comprising the compound and a use of the compound in the preparation of a drug for treating diseases such as osteoarthritis.
(FR) L'invention concerne un dérivé tricyclique condensé relatif au domaine technique des médicaments chimiques, son procédé de préparation et une application pharmaceutique de celui-ci. Le dérivé tricyclique condensé est un inhibiteur de l'aggrécanase-2 (ADAMTS-5). L'invention concerne également une composition pharmaceutique comprenant le composé et une utilisation du composé dans la préparation d'un médicament pour le traitement de maladies telles que l'arthrose.
(ZH) 一种涉及化学药物技术领域的并三环类衍生物、其制备方法及其在医药上的应用。所述并三环类衍生物是蛋白聚糖酶2(ADAMTS-5，Aggrecanase-2)的抑制剂。一种包含这些化合物的药物组合物以及将该化合物用于制备治疗骨关节炎等疾病的药物中的用途。
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