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1. WO2022007461 - IMMUNOMODULATOR

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Publication Number WO/2022/007461
Publication Date 13.01.2022
International Application No. PCT/CN2021/087548
International Filing Date 15.04.2021
IPC
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 413/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 271/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
271Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02not condensed with other rings
101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • 成都先导药物开发股份有限公司 HITGEN INC. [CN]/[CN]
Inventors
  • 李进 LI, Jin
  • 张登友 ZHANG, Dengyou
  • 白晓光 BAI, Xiaoguang
  • 周贤思 ZHOU, Xiansi
  • 洪新福 HONG, Xinfu
  • 徐凯 XU, Kai
  • 李清然 LI, Qingran
  • 陈欣 CHEN, Xin
  • 兰燕 LAN, Yan
Agents
  • 深圳市韦恩肯知识产权代理有限公司 WAYNE INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
202010611350.704.07.2020CN
202010658232.114.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IMMUNOMODULATOR
(FR) IMMUNOMODULATEUR
(ZH) 一种免疫调节剂
front page image
Abstract
(EN) Disclosed is an immunomodulator, and the present invention specifically relates to a compound for inhibiting IL-17A and an application of the compound serving as the immunomodulator in the preparation of a drug. Disclosed is an application of a compound represented by formula I or a stereoisomer thereof in preparing a drug for inhibiting IL-17A, and a new choice for clinically screening and/or preparing a drug for treating diseases related to IL-17A activity is provided.
(FR) La présente invention concerne un immunomodulateur, et en particulier un composé destiné à inhiber l'IL-17A et une utilisation du composé servant d'immunomodulateur dans la préparation d'un médicament. L'invention concerne l'utilisation d'un composé représenté par la formule I ou un stéréoisomère de celui-ci dans la préparation d'un médicament pour l'inhibition d'IL-17A, et offre une nouvelle option pour le criblage clinique et/ou la préparation d'un médicament pour le traitement de maladies associées à l'activité de l'IL-17A.
(ZH) 本发明公开了一种免疫调节剂，具体涉及一类抑制IL-17A的化合物及其作为免疫调节剂在制备药物中的用途。本发明公开了式（I）所示的化合物、或其立体异构体在制备抑制IL-17A类药物中的用途，为临床上筛选和/或制备与IL-17A活性相关的疾病的药物提供了一种新的选择。
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