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1. WO2021113665 - RAPAMYCIN ANALOGS AND USES THEREOF

Publication Number WO/2021/113665
Publication Date 10.06.2021
International Application No. PCT/US2020/063351
International Filing Date 04.12.2020
IPC
A61K 31/436 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
436the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/56 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K 31/663 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
C07D 498/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
18Bridged systems
Applicants
  • NAVITOR PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • O'NEILL, David, John
  • SAIAH, Eddine
  • KANG, Seong, Woo, Anthony
Agents
  • REID, Andrea, L., C.
  • ARICO, Joseph, W.
  • FLEMING, Paul, R.
  • OH, Euk, Charlie
  • NIHAN, Danielle, M.
  • WANG, Gang
  • DAVIS, Chad, E.
  • STEVENSON, Christian, P.
  • MANAS, Michael
  • MACKLIN, Todd, K.
Priority Data
62/944,16605.12.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RAPAMYCIN ANALOGS AND USES THEREOF
(FR) ANALOGUES DE LA RAPAMYCINE ET LEURS UTILISATIONS
Abstract
(EN)
The present invention provides compounds, compositions thereof, and methods of using the same. The present invention relates to compounds and methods useful for modulating mTORC1 activity. The invention also provides pharmaceutically acceptable compositions comprising provided compounds of the present invention and methods of using such compositions in the treatment of various disorders.
(FR)
La présente invention concerne des composés, des compositions de ceux-ci, et des procédés d'utilisation de ceux-ci. La présente invention concerne des composés et des procédés utiles pour moduler l'activité mTORC1. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant les composés de la présente invention et des procédés d'utilisation de telles compositions dans le traitement de divers troubles.
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