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1. WO2021113657 - TRIANTENNARY N-ACETYLGALACTOSAMINE MODIFIED HYDROXYL POLYAMIDOAMINE DENDRIMERS AND METHODS OF USE THEREOF

Publication Number WO/2021/113657
Publication Date 10.06.2021
International Application No. PCT/US2020/063342
International Filing Date 04.12.2020
IPC
A61K 47/56 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
A61K 47/61 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
61the organic macromolecular compound being a polysaccharide or a derivative thereof
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61K 47/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
A61K 47/61
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
61the organic macromolecular compound being a polysaccharide or a derivative thereof
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • ASHVATTHA THERAPEUTICS, INC. [US]/[US]
Inventors
  • CLELAND, Jeffrey
  • SHARMA, Rishi
  • SUN, Minghao
Agents
  • PABST, Patrea L.
  • RAYMOND, Adam S.
  • SHYNTUM, Yvonne Y.
  • YONGYE, Austin B.
  • HODGES, Robert A.
  • MONHEIT, Rivka D.
  • SARGSYAN, S. Anna
  • ZUNIGA, Carlos A.
  • WANG, Tanyu
  • XU, Xiaojin
Priority Data
62/943,70504.12.2019US
63/067,15518.08.2020US
63/086,10901.10.2020US
63/108,18630.10.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIANTENNARY N-ACETYLGALACTOSAMINE MODIFIED HYDROXYL POLYAMIDOAMINE DENDRIMERS AND METHODS OF USE THEREOF
(FR) DENDRIMÈRES DE POLYAMIDOAMINE D'HYDROXYLE MODIFIÉS PAR N-ACÉTYLGALACTOSAMINE TRIANTENNÉE ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN)
It has been established that dendrimers conjugated or complexed with the carbohydrate triantennary N-Acetylgalactosamine (triantennary-β-GalNAc) selectively accumulate within hepatocyte cells and selectively deliver therapeutic, prophylactic or diagnostic agents to the liver. Compositions of dendrimers complexed with triantennary-β-GalNAc and one or more agents to prevent, treat or diagnose a liver injury, liver disease or liver disorder in a subject in need thereof, and methods of use thereof, have been developed. The compositions are particularly suited for treating and/or ameliorating one or more symptoms of nonalcoholic fatty liver disease (NAFLD) and liver cancer, with decreased toxicity.
(FR)
Il a été établi que des dendrimères conjugués ou complexés avec la N-acétylgalactosamine triantennée glucidique (triantennée-β-GalNAc) s'accumulent sélectivement dans les cellules hépatocytaires et délivrent sélectivement des agents thérapeutiques, prophylactiques ou diagnostiques au foie. Des compositions de dendrimères complexés avec de la triantennée-β-GalNAc et un ou plusieurs agents pour prévenir, traiter ou diagnostiquer une lésion hépatique, une maladie hépatique ou un trouble hépatique chez un sujet en ayant besoin, et des méthodes d'utilisation de celles-ci, ont été développées. Les compositions sont particulièrement appropriées pour traiter et/ou améliorer un ou plusieurs symptômes de la stéatose hépatique non alcoolique (NAFLD) et du cancer du foie, avec une toxicité réduite.
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