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1. WO2021113397 - POLYMERIC PEG DRUG DELIVERY PLATFORMS AND METHODS

Publication Number WO/2021/113397
Publication Date 10.06.2021
International Application No. PCT/US2020/062939
International Filing Date 02.12.2020
IPC
A61F 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A61F 9/007 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
007Methods or devices for eye surgery
A61K 31/5575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
557Eicosanoids, e.g. leukotrienes
5575having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A61K 47/34 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Applicants
  • ONSELEX INC. [KR]/[KR]
  • SHIN, Ernest [US]/[US]
Inventors
  • SHIN, Ernest
  • KIM, Won Jong
Agents
  • BORDNER, Thomas
Priority Data
62/942,88503.12.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMERIC PEG DRUG DELIVERY PLATFORMS AND METHODS
(FR) PLATES-FORMES ET MÉTHODES D'ADMINISTRATION DE MÉDICAMENT PEG POLYMÈRE
Abstract
(EN)
The present invention relates generally to amphiphilic diblock and/or triblock copolymers and/or star-shaped block copolymers of biodegradable materials (e.g., PEG-b -PCL and PEG-a-PCL) as drug delivery platforms and to methods of producing, evaluating, administering, and treating subjects with the same. More particularly, the present invention provides poly(ethylene glycol)-b-poly(ε-caprolactone) and poly(ethylene glycol)-a-poly(ε-caprolactone) copolymers and copolymer-drug conjugates, aggregates, and supramolecular assemblies (e.g., micelles) as well as selective methods for associating one or more therapeutic drug (or prodrug) substances to the polymeric block copolymers.
(FR)
La présente invention concerne de manière générale des copolymères diblocs et/ou triblocs amphiphiles et/ou des copolymères séquencés en étoile de matériaux biodégradables (par exemple, le PEG-b-PCL et le PEG-a-PCL) en tant que plates-formes d'administration de médicament ainsi que des méthodes de fabrication, d'évaluation, d'administration et de traitement de sujets correspondantes. Plus particulièrement, la présente invention concerne des copolymères et des conjugués copolymère-médicament de poly(éthylène glycol)-b-poly(ε-caprolactone) et de poly(éthylène glycol)-a-poly(ε-caprolactone), des agrégats et des ensembles supramoléculaires (par exemple, des micelles) ainsi que des méthodes sélectives pour associer une ou plusieurs substances médicamenteuses thérapeutiques (ou promédicaments) aux copolymères séquencés polymères.
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