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1. WO2021110280 - AMINOACRIDINE AND AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS

Publication Number WO/2021/110280
Publication Date 10.06.2021
International Application No. PCT/EP2019/084067
International Filing Date 06.12.2019
IPC
C09B 15/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
15Acridine dyes
C09B 57/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
57Other synthetic dyes of known constitution
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C09B 15/00
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
15Acridine dyes
C09B 57/001
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
57Other synthetic dyes of known constitution
001Pyrene dyes
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. [DE]/[DE]
Inventors
  • FOMIN, Maksim A.
  • SAVICHEVA, Elizaveta
  • SEIKOWSKI, Jan
  • BELOV, Vladimir
  • HELL, Stefan W.
Agents
  • V. BEZOLD & PARTNER PATENTANWÄLTE - PARTG MBB
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINOACRIDINE AND AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS
(FR) COLORANTS AMINOACRIDINE ET AMINOPYRÈNE ET LEUR UTILISATION COMME MARQUEURS FLUORESCENTS, EN PARTICULIER POUR L’ANALYSE DES HYDRATES DE CARBONE
Abstract
(EN)
The invention relates to novel fluorescent dyes with multiple negatively charged groups in their ionized form which are 9-aminoacridines or 1-aminopyreneshaving of one of the following general formulae A-E: or salts or protonated forms thereof, wherein the ionizable groups are typically selected from the following: OH, SH, COOH, SO3H, OSO3H,SO2NHCN, P(O)(OH)2, P(O)(OH)2. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans, and to carbohydrate-dye conjugates comprising these dyes as well as to methods for preparing the same.
(FR)
L'invention concerne de nouveaux colorants fluorescents ayant de multiples groupes chargés négativement sous leur forme ionisée qui sont des 9-aminoacridines ou des 1-aminopyrènes ayant l'une des formules générales A-E suivantes : ou des sels ou des formes protonées de ceux-ci, les groupes ionisables étant typiquement sélectionnés parmi les suivants : OH, SH, COOH, SO3H, OSO3H,SO2NHCN, P(O)(OH)2, P(O)(OH)2. L'invention concerne en outre l'utilisation de ces colorants comme marqueurs fluorescents, en particulier pour la réduction de sucres et de glycanes, et des conjugués hydrate de carbone-colorant comprenant ces colorants ainsi que des procédés de préparation associés
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