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1. WO2022135457 - ANTI-PD-L1 ANTIBODY AND USE THEREOF

Publication Number WO/2022/135457
Publication Date 30.06.2022
International Application No. PCT/CN2021/140391
International Filing Date 22.12.2021
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • 广东菲鹏制药股份有限公司 GUANGDONG FEIPENG PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 路力生 LU, Lisheng
  • 霍永庭 HUO, Yongting
  • 张婵 ZHANG, Chan
  • 罗颖 LUO, Ying
  • 芦迪 LU, Di
  • 刘云鹏 LIU, Yunpeng
  • 符俊 FU, Jun
Agents
  • 北京超凡宏宇专利代理事务所(特殊普通合伙) CHOFN INTELLECTUAL PROPERTY
Priority Data
202011541107.923.12.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTI-PD-L1 ANTIBODY AND USE THEREOF
(FR) ANTICORPS ANTI-PD-L1 ET SON UTILISATION
(ZH) 一种抗PD-L1抗体及其应用
Abstract
(EN) The present disclosure relates to the field of biomedicine, in particular to an anti-PD-L1 antibody and the use thereof. The anti-PD-L1 antibody or the antigen-binding fragment thereof provided in the present disclosure binds to the PD-L1 protein with a high affinity and high specificity, can effectively block the interaction between PD-L1 expressed on a cell surface and PD-1, has the biological function activity of stimulating cytokine production, and has wide application prospects.
(FR) La présente divulgation relève du domaine de la biomédecine, et concerne en particulier un anticorps anti-PD-L1 et son utilisation. L'anticorps anti-PD-L1 ou le fragment de liaison à l'antigène de celui-ci fourni dans la présente invention se lie à la protéine PD-L1 avec une affinité élevée et une spécificité élevée, peut bloquer de manière efficace l'interaction entre PD-L1 exprimée sur une surface cellulaire et PD-1, a l'activité de fonction biologique de stimulation de la production de cytokine, et présente de larges perspectives d'application.
(ZH) 本公开涉及生物医药领域,具体而言,涉及一种抗PD-L1抗体及其应用。本公开提供的抗PD-L1抗体或其抗原结合片段与PD-L1蛋白高亲和力和高特异性结合,能够有效阻断细胞表面表达的PD-L1与PD-1的相互作用,具有刺激细胞因子产生的生物学功能活性,应用前景广泛。
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