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1. WO2021146391 - REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C–P BONDS

Publication Number WO/2021/146391
Publication Date 22.07.2021
International Application No. PCT/US2021/013391
International Filing Date 14.01.2021
IPC
C07F 9/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
C07F 9/6564 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
C07F 9/6578 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6578having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US]
Inventors
  • XU, Dongmin
  • RIVAS-BASCÓN, Nazaret
  • KNOUSE, Kyle W.
  • PADIAL, Natalia M.
  • ZHENG, Bin
  • VANTOUROUT, Julien C.
  • SCHMIDT, Michael A.
  • EASTGATE, Martin D.
  • BARAN, Phil S.
Agents
  • COVERT, John M.
  • BANOWIT, Donald R.
  • BEMBEN, Richard M.
  • BEZOS, Salvador M.
  • BLOCK, Daniel S.
  • BODENSTEIN, Matthew
  • CALVO, Paul A.
  • CAMARCE, Christian A.
  • CIMBALA, Michele A.
  • COLLER III, Richard D.
  • CONKLIN, Kyle
  • DESAI, Nirav N.
  • DURKIN, Tracy-Gene G.
  • EISENBERG, Jason D.
  • ELLISON, Eldora L.
  • ESMOND, Robert W.
  • FEATHERSTONE, Donald J.
  • FITZSIMMONS, Jason A.
  • FRUEAUF, Jeremiah B.
  • GAJEWSKI, Daniel
  • GILLENTINE, Marsha Rose
  • GLENN, Dallin G.
  • GOLDSTEIN, Jorge A.
  • HELVEY, Jeffrey T.
  • HICKS, Ross
  • HOLMAN, David H.
  • HOLOUBEK, Michelle K.
  • HOPFINGER, Todd
  • JACKMAN, Peter A.
  • KENTON, JR., Lestin L.
  • KIM, Ji Eun
  • KIM, Josephine
  • LAROCK, Adam C.
  • LEE, Michael Q.
  • LONGSWORTH, Gaby L.
  • MILLONIG, Robert C.
  • MUTSCHELKNAUS, Joseph
  • NANNENGA-COMBS, Bonnie
  • PHERO, Graham C.
  • PICKARD, Byron L.
  • POWERS III, R. Wilson
  • RAY, Michael B.
  • RICHARDSON, Ryan C.
  • ROSE GILLENTINE, Marsha
  • RYGIEL, Mark W.
  • SHEA, JR., Timothy J.
  • SOKOHL, Robert E.
  • SPECHT, Michael D.
  • STEFFE, Eric K.
  • STERLING, Deborah A.
  • STERNE, Robert Greene
  • TUMINARO, Jonathan
  • VARUGHESE, Dennies
  • VIRA, Chandrika
  • WRIGHT, Jon E.
  • YONAN, Daniel E.
Priority Data
62/962,06616.01.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C–P BONDS
(FR) RÉACTIFS ET LEUR UTILISATION POUR LA SYNTHÈSE ÉNANTIODIVERGENTE MODULAIRE DE LIAISONS C-P
Abstract
(EN)
The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.
(FR)
L'invention concerne des réactifs à base de P(V) chiraux et leurs utilisations pour la synthèse modulaire, échelonnable et stéréospécifique de phosphines chirales, d'oxydes de phosphine et d'oligonucléotides particuliers.
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