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1. WO2021146257 - CONCENTRATED SODIUM VALPROATE FOR RAPID DELIVERY

Publication Number WO/2021/146257
Publication Date 22.07.2021
International Application No. PCT/US2021/013201
International Filing Date 13.01.2021
IPC
A61K 31/19 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 31/4365 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US]
Inventors
  • PAI, Manjunath P.
  • BIESTERVELD, Ben
  • ALAM, Hasan
Agents
  • STAPLE, David W.
Priority Data
62/961,94316.01.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONCENTRATED SODIUM VALPROATE FOR RAPID DELIVERY
(FR) VALPROATE DE SODIUM CONCENTRÉ POUR ADMINISTRATION RAPIDE
Abstract
(EN)
Provided herein are pharmaceutical compositions comprising concentrated valproic acid (e.g., >200 mg/mL) for rapid delivery of high doses (e.g., 100-200 mg/kg) of valproic acid to subjects (e.g., intraosseous, intravenous, etc.), and methods of treating emergency injuries and conditions therewith.
(FR)
L'invention concerne des compositions pharmaceutiques comprenant de l'acide valproïque concentré (par exemple, > 200 mg/mL) pour une administration rapide de doses élevées (par exemple 100-200 mg/kg) d'acide valproïque à des sujets (par exemple, par voie intraosseuse, intraveineuse, etc.), et des procédés de traitement de lésions et d'états associés à caractère urgent.
Latest bibliographic data on file with the International Bureau