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1. WO2021145743 - MITOCHONDRIA-TARGETING PROTEIN AND USE THEREOF

Publication Number WO/2021/145743
Publication Date 22.07.2021
International Application No. PCT/KR2021/000651
International Filing Date 18.01.2021
IPC
C07K 7/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
18Kallidins; Bradykinins; Related peptides
C12N 15/63 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A61K 47/66 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
66the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
Applicants
  • 아주대학교산학협력단 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 김현미 KIM, Hyun-mi
  • 주일로 JOU, Ilo
Agents
  • 특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2020-000596116.01.2020KR
10-2021-000571715.01.2021KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) MITOCHONDRIA-TARGETING PROTEIN AND USE THEREOF
(FR) PROTÉINE CIBLANT LES MITOCHONDRIES ET SON UTILISATION
(KO) 미토콘드리아 표적 단백질 및 이의 용도
Abstract
(EN)
The present invention relates to STAT6 protein, which targets mitochondria, and a use thereof. More specifically, the present invention provides a mitochondria-targeting peptide, a pharmaceutical composition comprising a complex in which the mitochondria-targeting peptide and a pharmaceutically active substance are coupled, as an active ingredient for prevention or treatment of a disease associated with mitochondrial dysfunction, a pharmaceutical composition comprising STAT6 protein as an active ingredient for prevention or treatment of a disease associated with mitochondrial dysfunction, and a health functional food composition. The STAT6 protein accurately targets mitochondria and as such, can effectively migrate or disperse a protein or drug of interest into mitochondria, whereby a disease associated with mitochondrial dysfunction can be prevented or treated.
(FR)
La présente invention concerne une protéine STAT6 ciblant les mitochondries et son utilisation. Plus particulièrement, la présente invention concerne un peptide ciblant les mitochondries, une composition pharmaceutique comprenant un complexe dans lequel le peptide ciblant les mitochondries et une substance pharmaceutiquement active sont couplés, en tant que principe actif pour la prévention ou le traitement d'une maladie associée à un dysfonctionnement mitochondrial, une composition pharmaceutique comprenant la protéine STAT6 en tant que principe actif pour la prévention ou le traitement d'une maladie associée à un dysfonctionnement mitochondrial, et une composition alimentaire fonctionnelle de santé. La protéine STAT6 cible avec précision les mitochondries et, en tant que tel, peut migrer ou disperser de manière efficace une protéine ou un médicament d'intérêt dans les mitochondries, permettant de prévenir ou de traiter une maladie associée à un dysfonctionnement mitochondrial.
(KO)
본 발명은 미토콘드리아를 표적하는 STAT6 단백질 및 이의 용도에 관한 것으로, 상세하게는 미토콘드리아 표적용 펩타이드, 상기 미토콘드리아 표적용 펩타이드 및 약리학적 활성 물질이 결합된 복합체를 유효성분으로 포함하는 미토콘드리아 기능 장애 관련 질환 예방 또는 치료용 약학 조성물, STAT6 단백질을 유효성분으로 함유하는 미토콘드리아 기능 장애 관련 질환 예방 또는 치료용 약학 조성물 및 건강기능식품 조성물 등을 제공한다. 상기 STAT6 단백질은 미토콘드리아를 정확하게 타겟함으로써, 목적 단백질이나 약물 등을 미토콘드리아로의 효과적으로 이동 또는 분포시킬 수 있고, 이를 이용하여 미토콘드리아 기능 장애와 관련된 질환을 예방 또는 치료할 수 있다.
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