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1. WO2021143573 - DISUBSTITUTED PEGYLATED INTERLEUKIN 2, PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2021/143573
Publication Date 22.07.2021
International Application No. PCT/CN2021/070268
International Filing Date 05.01.2021
IPC
C07K 14/55 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
55IL-2
C07K 1/107 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
107by chemical modification of precursor peptides
A61K 38/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
A61K 47/60 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • 天津键凯科技有限公司 JENKEM TECHNOLOGY CO., LTD. (TIANJIN) [CN]/[CN]
Inventors
  • 王庆彬 WANG, Qingbin
  • 齐杰 QI, Jie
  • 李玉 LI, Yu
Agents
  • 北京领科知识产权代理事务所(特殊普通合伙) BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP)
Priority Data
202010044132.X15.01.2020CN
202011168335.628.10.2020CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DISUBSTITUTED PEGYLATED INTERLEUKIN 2, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) INTERLEUKINE 2 PÉGYLÉE DISUBSTITUÉE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 二取代PEG化白细胞介素2及其制备方法、应用
Abstract
(EN)
A preparation method for a disubstituted PEGylated interleukin 2, comprising the steps of: (1) PEGylating IL-2 to obtain a PEGylated interleukin crude product; (2) performing gel chromatography filtration to remove free interleukin 2 from the crude product; (3) performing affinity chromatography on the product in step (2) by means of an α receptor column, and collecting a flow-through peak component and an elution peak component; (4) respectively performing ion exchange separation on the flow-through peak component and the elution peak component in step (3); and (5) collecting components of the disubstituted PEGylated Interleukin 2.
(FR)
Procédé de préparation d'une interleukine 2 PÉGylée disubstituée, comprenant les étapes suivantes : (1) la PÉGylation de l'IL-2 pour obtenir un produit brut d'interleukine PÉGylée ; (2) la réalisation d'une filtration par chromatographie sur gel pour éliminer l'interleukine 2 libre du produit brut ; (3) la réalisation d'une chromatographie d'affinité sur le produit à l'étape (2) au moyen d'une colonne de récepteur α, et la collecte d'un composant de pic de circulation et d'un composant de pic d'élution ; (4) la réalisation respective d'une séparation d'échange d'ions sur le composant de pic traversant et le composant de pic d'élution dans l'étape (3) ; et (5) la collecte des composants de l'interleukine 2 PÉGylée disubstituée.
(ZH)
一种二取代PEG化白细胞介素2的制备方法,包括步骤:(1)PEG化IL-2得到PEG化白细胞介素粗产物;(2)凝胶层析过滤去除粗产物中游离白细胞介素2;(3)将步骤(2)中的产物用α受体柱亲和层析,收集流穿峰组分和洗脱峰组分;(4)分别对步骤(3)中的流穿峰组分和洗脱峰组分进行离子交换分离;(5)收集二取代PEG化白细胞介素2的组分。
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