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1. WO2021142835 - STRENGTHENED RECEPTOR FOR IMPROVING IMMUNE CELL FUNCTION

Publication Number WO/2021/142835
Publication Date 22.07.2021
International Application No. PCT/CN2020/073017
International Filing Date 19.01.2020
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 北京卡替医疗技术有限公司 CHINEO MEDICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 谷为岳 GU, Weiyue
Agents
  • 北京卓孚律师事务所 IPFAITH PARTNERS
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) STRENGTHENED RECEPTOR FOR IMPROVING IMMUNE CELL FUNCTION
(FR) RÉCEPTEUR RENFORCÉ POUR AMÉLIORER LA FONCTION DE CELLULES IMMUNITAIRES
(ZH) 一种提升免疫细胞功能的增强受体
Abstract
(EN)
The present invention provides a strengthened receptor for improving immune cell function, a related composition, and a cell. Said strengthened receptor is a transmembrane protein, a fusion protein is constituted from intracellular and extracellular domains, wherein the extracellular domain can be combined with a target cell, and the intracellular domain signaling pathway function can be activated, thereby increasing the activation level of an immune cell, overcoming an inhibitory effect of the target cell micro-environment on immune cells, and strengthening an immunotherapy effect.
(FR)
La présente invention concerne un récepteur renforcé pour améliorer la fonction de cellules immunitaires, une composition associée et une cellule. Ledit récepteur renforcé est une protéine transmembranaire, une protéine de fusion est constituée de domaines intracellulaires et extracellulaires, le domaine extracellulaire pouvant être combiné à une cellule cible, et la fonction de voie de signalisation de domaine intracellulaire peut être activée, ce qui permet d'augmenter le niveau d'activation d'une cellule immunitaire, de surmonter un effet inhibiteur du micro-environnement cellulaire cible sur des cellules immunitaires, et de renforcer un effet d'immunothérapie.
(ZH)
本发明提供了一种提升免疫细胞功能的增强受体,和相关组合物及细胞。该增强受体是一种跨膜蛋白,由胞外和胞内两个结构域组成融合蛋白,其中胞外结构域可结合靶细胞,并启动胞内结构域信号通路的功能,从而提升免疫细胞的活化水平,克服靶细胞微环境对免疫细胞的抑制作用,增强免疫治疗效果。
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