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1. WO2021142815 - BERBERINE AND COPTISINE, OR ACTIVE METABOLITES THEREOF, AND APPLICATION OF SALTS THEREOF IN MEDICATION FOR PREVENTING AND/OR TREATING URIC ACID NEPHROPATHY

Publication Number WO/2021/142815
Publication Date 22.07.2021
International Application No. PCT/CN2020/072901
International Filing Date 18.01.2020
IPC
A61K 31/4375 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 19/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
A61P 13/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • 中国医学科学院药物研究所 INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES [CN]/[CN]
Inventors
  • 蒋建东 JIANG, Jiandong
  • 王琰 WANG, Yan
  • 潘利斌 PAN, Libin
  • 赵朕雄 ZHAO, Zhenxiong
  • 丛林 CONG, Lin
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BERBERINE AND COPTISINE, OR ACTIVE METABOLITES THEREOF, AND APPLICATION OF SALTS THEREOF IN MEDICATION FOR PREVENTING AND/OR TREATING URIC ACID NEPHROPATHY
(FR) BERBÉRINE ET COPTISINE, OU MÉTABOLITES ACTIFS ASSOCIÉS ET APPLICATION DE SELS ASSOCIÉS DANS UN MÉDICAMENT DESTINÉ À LA PRÉVENTION ET/OU AU TRAITEMENT D'UNE NÉPHROPATHIE À L'ACIDE URIQUE
(ZH) 小檗碱、黄连碱或其活性代谢产物、及其盐在预防和/或治疗尿酸性肾病药物中的应用
Abstract
(EN)
Disclosed are berberine represented by structural formula (I), coptisine represented by structural formula (II), berberine active metabolites represented by structural formulas (III), (IV), (V), (VI), (VII), (VIII), and (Ⅸ), including jatrorrhizine, dihydroberberine, thalifendine, berberrubine, demethyleneberberine, palmatine, and columbamine, and application of pharmaceutically acceptable salts thereof in preparation of a medication for preventing and/or treating uric acid nephropathy (gouty nephropathy).
(FR)
La présente invention concerne la berbérine représentée par la formule développée (I), la coptisine représentée par la formule développée (II), les métabolites actifs de la berbérine représentés par les formules développées (III) (IV) (V) (VI) (VII) (VIII) et (IX), comprenant de la jatrorrhizine, de la dihydroberbérine, de la taliféndine, de la berbérrubine, de la déméthylèneberbérine, de la palmatine et de la columbamine et l'application de sels pharmaceutiquement acceptables associés dans la préparation d'un médicament destiné à prévenir et/ou à traiter la néphropathie à l'acide urique (néphropathie goutteuse).
(ZH)
结构式(I)所示的小檗碱,结构式(II)所示的黄连碱,结构式(III)、(IV)、(V)、(VI)、(VII)、(VIII)、(Ⅸ)所示的小檗碱活性代谢产物药根碱、二氢小檗碱、唐松草分定、小檗红碱、去亚甲基小檗碱、巴马汀、非洲防己碱,以及它们药学上可接受的盐在制备预防和/或治疗尿酸性肾病(痛风肾病)药物中的应用。
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