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1. WO2021079010 - ELECTROPHILIC NITROALKENE BENZOIC ACID DERIVATES AS THERAPEUTIC DRUGS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE CONDITIONS

Publication Number WO/2021/079010
Publication Date 29.04.2021
International Application No. PCT/EP2020/080088
International Filing Date 26.10.2020
IPC
A61K 31/192 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
04Nitro compounds
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
04Nitro compounds
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • INSTITUT PASTEUR DE MONTEVIDEO [UY]/[UY]
  • UNIVERISDAD DE LA REPUBLICA [UY]/[UY]
  • BATTHYÁNY, Carlos [AT]/[UY]
Inventors
  • BATTHYÁNY, Carlos
  • BARBEITO, Luis
  • ESCANDE, Carlos
  • BARBURU, Sofía
  • LÓPEZ, Gloria Virginia
  • PORCAL QUINTA,, Arturo Williams
  • INGOLD, Mariana
  • COLELLA, Lucia
Agents
  • MILTON, Christopher
Priority Data
62/925,38324.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ELECTROPHILIC NITROALKENE BENZOIC ACID DERIVATES AS THERAPEUTIC DRUGS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE CONDITIONS
(FR) DÉRIVÉS D'ACIDE NITROALCÈNE BENZOÏQUE ÉLECTROPHILE EN TANT QUE MÉDICAMENTS THÉRAPEUTIQUES DANS LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (SLA) ET D'AUTRES ÉTATS NEURODÉGÉNÉRATIFS
Abstract
(EN)
This invention relates to the use of nitroalkene derivatives for the treatment of neurodegenerative conditions in mammals in which neuroinflammation is a contributing factor, such as in amyotrophic lateral sclerosis (ALS).
(FR)
La présente invention concerne l'utilisation de dérivés de nitroalcène pour le traitement d'états neurodégénératifs chez des mammifères dans lesquels la neuro-inflammation est un facteur contributif, tel que dans la sclérose latérale amyotrophique (SLA).
Also published as
Latest bibliographic data on file with the International Bureau