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1. WO2021078991 - TREATMENT OF CONDITIONS OF THE NERVOUS SYSTEM

Publication Number WO/2021/078991
Publication Date 29.04.2021
International Application No. PCT/EP2020/079979
International Filing Date 25.10.2020
IPC
A61K 31/37 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 31/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • KWOK, Jessica [GB]/[GB]
  • FOSTER, Richard [GB]/[GB]
  • DUNCAN, James [GB]/[GB]
Inventors
  • KWOK, Jessica
  • FOSTER, Richard
  • DUNCAN, James
Agents
  • PURDYLUCEY INTELLECTUAL PROPERTY
Priority Data
62/926,00125.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF CONDITIONS OF THE NERVOUS SYSTEM
(FR) TRAITEMENT D'AFFECTIONS DU SYSTÈME NERVEUX
Abstract
(EN)
Provided is 4-methylumbelliferone, derivatives and salts thereof, or a composition comprising same for use in the treatment of a condition of the nervous system in a subject. Preferably, the condition is one associated with a scar, such as a glial scar. Typically, the condition of the nervous system is selected from the group comprising conditions caused by trauma, injury, infection, degeneration, structural defects, tumours, blood flow disruption. The neural and other lesions are made permeable and repairable.
(FR)
L'invention concerne le composé 4-méthylumbelliférone, des dérivés et des sels de celui-ci, ou une composition le comprenant et destinée à être utilisée dans le traitement d'une affection du système nerveux chez un sujet. De préférence, l'affection est associée à une cicatrice, telle qu'une cicatrice gliale. Généralement, l'affection du système nerveux est choisie dans le groupe comprenant des affections provoquées par un traumatisme, une lésion, une infection, une dégénérescence, des anomalies structurelles, des tumeurs, une interruption du flux sanguin. Les lésions neurales et d'autres lésions sont rendues perméables et réparables.
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