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1. WO2021051095 - SPORE-BASED PROBIOTIC COMPOSITION FOR MODULATION OF MICROBIOME IN HUMANS

Publication Number WO/2021/051095
Publication Date 18.03.2021
International Application No. PCT/US2020/050761
International Filing Date 14.09.2020
IPC
C12N 1/20 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
A61P 1/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61K 35/742 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
CPC
A61K 35/741
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
A61K 35/742
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A61K 35/745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Applicants
  • MICROBIOME LABS, LLC [US]/[US]
Inventors
  • KRISHNAN, Kiran
  • KRIZ, Dale, M.
  • BAYNE, Thomas, F.
Agents
  • CARRERA, George, M.
  • NEYMEYER-TYNKOV, Valerie
  • KRIT, Jonathan, J.
  • TALATI, Ashish
Priority Data
62/899,30112.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SPORE-BASED PROBIOTIC COMPOSITION FOR MODULATION OF MICROBIOME IN HUMANS
(FR) COMPOSITION PROBIOTIQUE À BASE DE SPORES POUR LA MODULATION DU MICROBIOME CHEZ L'HOMME
Abstract
(EN)
A spore-based probiotic composition is provided that comprises at least one viable probiotic microorganism having a biological or therapeutic effect on microbiome in humans. One exemplary composition contains five different strains of Bacillus spp.. Also provided are methods of producing spore-based probiotic compositions. A validated in vitro gut model which is a simulated human intestinal microbial ecosystem reactor was used to assess the long-term effect of the composition on microbial metabolic activity and community composition. The results support use of the composition in protecting against obesity-related disorders, metabolic disorders, inflammation, and cancer, for example. A method for modulating microbial metabolic activity and/or modulating microbial community composition in a human subject is described.
(FR)
L'invention concerne une composition probiotique à base de spores qui comprend au moins un micro-organisme probiotique viable présentant un effet biologique ou thérapeutique sur le microbiome chez l'être humain. Une composition donnée à titre d'exemple contient cinq souches différentes de Bacillus spp. L'invention concerne également des procédés de production de compositions probiotiques à base de spores. Un modèle d'intestin in vitro validé qui constitue un réacteur d'écosystème microbien intestinal humain simulé a été utilisé pour évaluer l'effet à long terme de la composition sur une activité métabolique microbienne et une composition de communauté microbienne. Les résultats appuient l'utilisation de la composition pour fournir une protection contre les troubles liés à l'obésité, les troubles métaboliques, l'inflammation et le cancer, par exemple. L'invention concerne également une méthode de modulation de l'activité métabolique microbienne et/ou de modulation de la composition de la communauté microbienne chez un sujet humain.
Also published as
Latest bibliographic data on file with the International Bureau