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1. WO2022160057 - MULTABODY CONSTRUCTS, COMPOSITIONS, AND METHODS

Publication Number WO/2022/160057
Publication Date 04.08.2022
International Application No. PCT/CA2022/050122
International Filing Date 28.01.2022
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 39/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
A61K 47/62 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
A61K 47/68 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Applicants
  • THE HOSPITAL FOR SICK CHILDREN [CA]/[CA]
Inventors
  • JULIEN, Jean-philippe
  • DIEZ, Edurne Rujas
Agents
  • LOWTHERS, Erica L.
  • MCMANUS, Kimberly A.
  • SINDEN, William K.
  • REECE, Pia-Lauren
  • BARTOSZEWICZ, Lola A.
  • SABETA, Anton C.
  • MILLMAN, Jay M.
  • HUNDAL, Steve S.
Priority Data
63/142,70428.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MULTABODY CONSTRUCTS, COMPOSITIONS, AND METHODS
(FR) CONSTRUCTIONS DE MULTICORPS, COMPOSITIONS ET PROCÉDÉS
Abstract
(EN) In aspects, a fusion protein comprises a nanocage monomer or a subunit thereof linked to an Fc monomer, wherein a plurality of the fusion proteins are capable of self-assembling to form a nanocage comprising one or more Fc dimers. In aspects, a fusion protein comprises a nanocage monomer or a subunit thereof linked to an Fc monomer or scFc fragment at the C-terminus of the nanocage monomer or subunit thereof, wherein a plurality of the fusion proteins are capable of self-assembling to form a nanocage.
(FR) Selon certains aspects, l'invention concerne une protéine de fusion comprenant un monomère de nanocage ou une sous-unité de celui-ci liée à un monomère Fc, une pluralité de protéines de fusion étant capables de s'auto-assembler pour former une nanocage comprenant un ou plusieurs dimères Fc. Selon certains aspects, une protéine de fusion comprenant un monomère de nanocage ou une sous-unité de celui-ci liée à un monomère Fc ou à un fragment scFc au niveau de l'extrémité C-terminale du monomère de nanocage ou de la sous-unité de celui-ci, une pluralité de protéines de fusion étant capables de s'auto-assembler pour former une nanocage.
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