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1. WO2022160056 - DMT SALTS AND THEIR USE TO TREAT BRAIN INJURY

Publication Number WO/2022/160056
Publication Date 04.08.2022
International Application No. PCT/CA2022/050121
International Filing Date 28.01.2022
IPC
A61K 31/4045 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61K 31/194 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
194having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A61K 31/455 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
455Nicotinic acid, i.e. niacin; Derivatives thereof, e.g. esters, amides
A61M 5/142 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
A61M 5/168 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
A61P 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • ALGERNON PHARMACEUTICALS INC. [CA]/[CA]
Inventors
  • WILLIAMS, Mark
  • BRYAN, Christopher
Agents
  • RIDOUT & MAYBEE LLP
  • HELLER, David J.
Priority Data
63/143,67929.01.2021US
63/143,68829.01.2021US
63/143,69529.01.2021US
63/187,68112.05.2021US
63/273,61229.10.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DMT SALTS AND THEIR USE TO TREAT BRAIN INJURY
(FR) SELS DE DMT ET LEUR UTILISATION POUR TRAITER UNE LÉSION CÉRÉBRALE
Abstract
(EN) DMT nicotinate and DMT pamoate are disclosed. DMT and its salts are found useful in the treatment of stroke, multiple sclerosis, Parkinson's disease, and traumatic brain injury. They are particularly useful in the treatment of haemorrhagic stroke. They are particularly useful in the immediate treatment of undiagnosed stroke. They are for use with anti-hypertensives when treating haemorrhagic stroke or TBI. Also taught are preferred dosages and serum levels of DMT, an intravenous pump device containing a pharmaceutically acceptable form of DMT. The pump may be configured to provide a specific dose and/or duration. The pump may have a locking system to prevent access to said compound or said DMT above the dose.
(FR) L'invention concerne la nicotinate DMT et la pamoate DMT. La DMT et ses sels s'avèrent utiles dans le traitement d'un accident vasculaire cérébral, de la sclérose en plaques, de la maladie de Parkinson et d'une lésion cérébrale traumatique. Ils sont particulièrement utiles dans le traitement d'une attaque hémorragique. Ils sont notamment utiles dans le traitement immédiat d'un accident vasculaire cérébral non diagnostiqué. Ils sont destinés à être utilisés avec des anti-hypertenseurs lors du traitement d'une attaque hémorragique ou d'une lésion cérébrale traumatique (TBI). L'invention concerne également des dosages et des taux sériques préférés de DMT, un dispositif de pompe intraveineuse contenant une forme pharmaceutiquement acceptable de DMT. La pompe peut être conçue pour fournir une dose et/ou une durée spécifiques. La pompe peut avoir un système de verrouillage pour empêcher l'accès audit composé ou à ladite DMT dépassant la dose.
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