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1. WO2022160022 - LONG-LASTING RESORBABLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRE-CONCENTRATED PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS AND METHOD

Publication Number WO/2022/160022
Publication Date 04.08.2022
International Application No. PCT/BR2021/050061
International Filing Date 08.02.2021
IPC
A61K 9/56 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
52Sustained or differential release type
54containing discrete particles with coatings of different thicknesses or different materials
56Organic coatings
A61K 31/155 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
A61K 31/4985 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/4439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 38/26 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • LUIZ PERACCHI, Edson [BR]/[BR]
Inventors
  • LUIZ PERACCHI, Edson
Agents
  • ANTONIO NUNES, Marcos Antonio Nunes
Priority Data
BR 10 2021 001712 029.01.2021BR
Publication Language Portuguese (pt)
Filing Language Portuguese (PT)
Designated States
Title
(EN) LONG-LASTING RESORBABLE SUBCUTANEOUS IMPLANT WITH PROLONGED RELEASE OF PRE-CONCENTRATED PHARMACOLOGICALLY ACTIVE SUBSTANCE IN POLYMER FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS AND METHOD
(FR) IMPLANT SOUS-CUTANÉ RÉABSORBABLE DE LONGUE DURÉE À LIBÉRATION PROLONGÉE DE SUBSTANCE PHARMACOLOGIQUEMENT ACTIVE PRÉ-CONCENTRÉE EN POLYMÈRE POUR LE TRAITEMENT DU DIABÈTE DE TYPE 2 ET PROCÉDÉ
(PT) IMPLANTE SUBCUTÂNEO REABSORVÍVEL DE LONGA DURAÇÃO COM LIBERAÇÃO PROLONGADA DE SUBSTÂNCIA FARMACOLOGICAMENTE ATIVA PRÉ-CONCENTRADA EM POLÍMERO PARA TRATAMENTO DA DIABETES MELLITUS TIPO 2 E PROCESSO
Abstract
(EN) The present invention patent pertains to the healthcare sector and comprises a long-lasting resorbable subcutaneous implant with prolonged release of a pre-concentrated pharmacologically active substance in a polymer for the treatment of type 2 diabetes mellitus. The biodegradable implant is inserted subcutaneously and provides continuous release of the active substance for an extended period of time. The implant is preferably made up of particles of the active substance uniformly dispersed in a bioerodible and bioabsorbable polymer matrix. The implants can be of any size, shape and structure that enable manufacture and subcutaneous insertion. However, the implants must have geometric shapes that retain their surface area over time to ensure a more constant and uniform release of the active substance.
(FR) La présente demande de brevet d'invention relève du secteur médical et comprend un implant sous-cutané réabsorbable de longue durée à libération prolongée de substance pharmacologiquement active pré-concentrée en polymère pour le traitement du diabète de type 2. L’implant biodégradable est inséré par voie sous-cutanée et présente une libération continue du principe actif pendant une période de temps prolongée. Ledit implant est formé, de préférence, de particules du principe actif dispersées de manière homogène dans une matrice polymère bioérodable et bioabsorbable. Les implants peuvent présenter une quelconque dimension, forme ou structure qui facilite leur fabrication et leur insertion sous-cutanée, toutefois, pour obtenir une libération plus constante et uniforme du principe actif, il est nécessaire d'utiliser des formes géométriques qui gardent leur surface active au cours du temps.
(PT) O privilégio de invenção é voltado ao setor de saúde e compreende um implante subcutâneo reabsorvível de longa duração com liberação prolongada de substância farmacologicamente ativa pré-concentrada em polímero para tratamento da diabetes mellitus tipo 2. O implante biodegradável é inserido por via subcutânea e possui liberação contínua do ativo por um período de tempo prolongado. O implante é preferencialmente formado por partículas do ativo dispersas homogeneamente em uma matriz polimérica bioerodível e bioabsorvível. Os implantes podem ter qualquer tamanho, forma ou estrutura que facilite a sua fabricação e inserção subcutânea, entretanto, para se obter uma liberação mais constante e uniforme do ativo é necessário utilizar formas geométricas que mantém sua área superficial ao longo do tempo.
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