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1. WO2022134047 - HUMANIZED ANTI-C5 ANTIBODIES AND FACTOR H FUSION PROTEINS AND USES THEREOF

Publication Number WO/2022/134047
Publication Date 30.06.2022
International Application No. PCT/CN2020/139556
International Filing Date 25.12.2020
IPC
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US]
  • KIRA PHARMACEUTICALS (SUZHOU) LTD. [CN]/[CN]
Inventors
  • SONG, Wenchao
  • MIWA, Takashi
  • SATO, Sayaka
  • GULLIPALLI, Damodara Rao
  • TSUI, Ping
  • ZHU, Xihua
  • ZHANG, Jianjun
  • XU, Yingying
Agents
  • KANGXIN PARTNERS, P.C.
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED ANTI-C5 ANTIBODIES AND FACTOR H FUSION PROTEINS AND USES THEREOF
(FR) ANTICORPS ANTI-C5 HUMANISÉS ET PROTÉINES DE FUSION DU FACTEUR H ET LEURS UTILISATIONS
Abstract
(EN) Provided is inhibition of the complement signaling using an anti-C5 antibody or fusion protein thereof. Specifically, provided are methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof.
(FR) L'invention se rapporte à l'inhibition de la signalisation du complément à l'aide d'un anticorps anti-C5 ou d'une protéine de fusion correspondante. De façon spécifique, l'invention concerne des procédés de traitement d'une maladie médiée par le complément ou d'un trouble médié par le complément chez un individu par la mise en contact de l'individu avec une protéine de fusion d'anticorps anti-C5 correspondante.
Latest bibliographic data on file with the International Bureau