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1. WO2021194826 - RECOMBINANT SARS-COV-2 SPIKE PROTEIN AND USES THEREOF

Publication Number WO/2021/194826
Publication Date 30.09.2021
International Application No. PCT/US2021/022848
International Filing Date 17.03.2021
IPC
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/535 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
532Production of labelled immunochemicals
535with enzyme label
CPC
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
G01N 33/6854
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
Applicants
  • ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]/[US]
Inventors
  • KRAMMER, Florian
  • FIRPO-BETANCOURT, Adolfo
  • CORDON-CARDO, Carlos
  • MENDU, Damodara, Rao
  • SIMON, Viviana
  • AMANAT, Fatima
  • STADLBAUER, Daniel
Agents
  • CHHEDA, Jennifer, J.
  • INSOGNIA, Anthony, M.
  • MCNICHOLAS, Janet, M.
  • NIX, Kelsey
  • ANTLER, Adriane, M.
Priority Data
62/994,25224.03.2020US
63/018,45730.04.2020US
63/020,50305.05.2020US
63/024,43613.05.2020US
63/051,85814.07.2020US
63/059,92431.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) RECOMBINANT SARS-COV-2 SPIKE PROTEIN AND USES THEREOF
(FR) PROTÉINE DE SPICULE DE SARS-COV-2 DE RECOMBINAISON ET SES UTILISATIONS
Abstract
(EN) Provided herein are recombinant SARS-CoV-2 spike proteins, cells producing such proteins, and kits comprising such proteins. Also provided herein are compositions comprising recombinant SARS-CoV-2 spike proteins and methods of detecting antibodies using such SARS-CoV-2 spike proteins.
(FR) L'invention concerne des protéines de spicule de SARS-CoV-2 de recombinaison, des cellules produisant de telles protéines, et des kits comprenant de telles protéines. L'invention concerne également des compositions comprenant des protéines de spicule de SARS-CoV-2 de recombinaison et des méthodes de détection d'anticorps à l'aide de telles protéines de spicule de SARS-CoV-2.
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