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1. WO2022094722 - METHODS FOR SYSTEMATICALLY ASSESSING LOCAL INFLAMMATION AND ACTIVE REPAIR

Publication Number WO/2022/094722
Publication Date 12.05.2022
International Application No. PCT/CA2021/051582
International Filing Date 05.11.2021
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
A61K 31/4045 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61K 31/4412 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4412having oxo groups directly attached to the heterocyclic ring
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 1/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • KEYINTEL MEDICAL INC. [CA]/[CA]
Inventors
  • TSUI, Florence Wing Ling
  • LIN, Aifeng
  • PRITZKER, Kenneth Phillip Henry
  • INMAN, Robert Davies
Agents
  • BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.
Priority Data
63/109,89305.11.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR SYSTEMATICALLY ASSESSING LOCAL INFLAMMATION AND ACTIVE REPAIR
(FR) PROCÉDÉS POUR ÉVALUER SYSTÉMATIQUEMENT UNE INFLAMMATION LOCALE ET UNE RÉPARATION ACTIVE
Abstract
(EN) Methods of assessing, monitoring and/or predicting clinical disease activity, treatment response, disease progression, and/or active repair for chronic inflammatory disease such as axial spondyloarthritis are provided based on the level and/or pattern of LCN2, LCN2-MMP9 and/or OSM.
(FR) L'invention concerne des procédés d'évaluation, de surveillance et/ou de prédiction de l'activité d'une maladie clinique, de la réponse au traitement, de la progression d'une maladie et/ou de la réparation active pour une maladie inflammatoire chronique telle qu'une spondylarthrite axiale, sur la base du niveau et/ou du profil de LCN2, LCN2-MMP9 et/ou OSM.
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