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1. WO2022126119 - METHODS AND SYSTEMS FOR DETECTION AND ANALYSIS OF ANGIOTENSIN BINDING ANTIBODIES

Publication Number WO/2022/126119
Publication Date 16.06.2022
International Application No. PCT/US2021/072823
International Filing Date 09.12.2021
IPC
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12Q 1/70 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • THE UNIVERSITY OF CHICAGO [US]/[US]
Inventors
  • SWARTZ, Melody
  • BRIQUEZ, Priscilla
  • HUBBELL, Jeffrey
Agents
  • STELLMAN, Laurie
Priority Data
63/123,19909.12.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND SYSTEMS FOR DETECTION AND ANALYSIS OF ANGIOTENSIN BINDING ANTIBODIES
(FR) MÉTHODES ET SYSTÈMES DE DÉTECTION ET D'ANALYSE D'ANTOCORPS DE LIAISON À L'ANTIGIOTENSINE
Abstract
(EN) Aspects of the disclosure are directed to methods, systems, and compositions for detecting antibodies capable of binding to angiotensin II. Certain aspects comprise detection of antibodies capable of binding to angiotensin II in a sample from a subject, where the subject has or has had a coronavirus infection, such as a SARS-CoV-2 infection. Also disclosed are vaccine compositions comprising a portion of SARS-CoV-2 Spike protein, where such compositions do not induce generation of angiotensin Il-binding antibodies.
(FR) Selon certains aspects, la divulgation concerne des méthodes, des systèmes et des compositions de détection d'anticorps pouvant se lier à l'angiotensine II. Certains aspects font appel à la détection d'anticorps pouvant se lier à l'angiotensine II dans un échantillon provenant d'un sujet, le sujet ayant ou ayant eu une infection par coronavirus, telle qu'une infection par le SARS-CoV-2. L'invention divulgue également des compositions de vaccin comprenant une partie de la protéine de spicule du SARS-CoV-2, de telles compositions n'induisant pas de génération d'anticorps de liaison à l'angiotensine II.
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