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1. WO2021202158 - NESTED RPA AND COMPETITIVE REFERENCE STANDARD

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Publication Number WO/2021/202158
Publication Date 07.10.2021
International Application No. PCT/US2021/023594
International Filing Date 23.03.2021
IPC
C12Q 1/70 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
CPC
C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
C12Q 1/701
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
70involving virus or bacteriophage
701Specific hybridization probes
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • SPRINGER, Michael
Agents
  • BRAICH, Ravinderjit S.
  • FITZGERALD, Mark J.
  • RESNICK, David S.
  • EISENSTEIN, Ronald I.
  • BENN, Susanna C.
  • CROSBY, David F.
  • HUFF, Shayne Y.
  • PTASHKA, Teresa A.
  • KLING, Nicole D.
Priority Data
63/003,55501.04.2020US
63/003,57601.04.2020US
63/006,37207.04.2020US
63/031,14428.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NESTED RPA AND COMPETITIVE REFERENCE STANDARD
(FR) RPA IMBRIQUÉ ET ÉTALON DE RÉFÉRENCE COMPÉTITIF
front page image
Abstract
(EN) The technology described herein is directed to methods, kits, and systems for detecting a target nucleic acid, such as a small amount of viral RNA. In one aspect, described herein are methods of detecting the target nucleic acid. In other aspects, described herein are kits and systems suitable to practice the methods described herein to detect the target nucleic acid. The technology described herein is also directed to methods, kits, and systems for detecting nucleotide polymorphism in a target nucleic acid, such as a small amount of viral RNA to distinguish closely related viruses.
(FR) La technologie décrite dans la présente invention concerne des procédés, des kits et des systèmes de détection d'un acide nucléique cible, tel qu'une petite quantité d'ARN viral. Selon un aspect, l'invention concerne des procédés de détection de l'acide nucléique cible. Selon d'autres aspects, l'invention concerne des kits et des systèmes appropriés pour mettre en œuvre les procédés de l'invention pour détecter l'acide nucléique cible. La technologie décrite dans la présente invention concerne également des procédés, des kits et des systèmes pour détecter un polymorphisme nucléotidique dans un acide nucléique cible, tel qu'une petite quantité d'ARN viral pour distinguer des virus étroitement apparentés.
Latest bibliographic data on file with the International Bureau
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