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The present invention is directed to compositions and methods for inducing artificial biological mimicry in a mammal to mimic the favorable immune advantages present in a bat in another mammal, particularly a human subject, and thereby prevent and/or treat COVID-19 and other diseases by administering to the subject a combination of active agents comprising two or more active agents comprising an inhibitor of inflammasome NLRP3, an inhibitor of one or more priming or activation signals of inflammasome NLRP3, and/or an activator of the inhibitor of one or more priming or activation signals of inflammasome NLRP3 alone or in combination with one or more modulators of Kallikrein-Kinin System (KKS) dysregulation, one or more modulators of Renin Aldosterone Angiotensin System (RAAS) dysregulation, one or more modulators of protease dysregulation, and/or one or more modulators of cytokine dysregulation. Pharmaceutical compositions, methods of treatment, methods of genetic testing, and packaged kits are provided.