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1. WO2022140605 - ADENOVIRAL SEROTYPE 35 HELPER VECTORS

Publication Number WO/2022/140605
Publication Date 30.06.2022
International Application No. PCT/US2021/064954
International Filing Date 22.12.2021
IPC
A61K 35/761 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
761Adenovirus
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
CPC
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2710/10321
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10321Viruses as such, e.g. new isolates, mutants or their genomic sequences
C12N 2710/10343
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10341Use of virus, viral particle or viral elements as a vector
10343viral genome or elements thereof as genetic vector
C12N 2710/10344
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10341Use of virus, viral particle or viral elements as a vector
10344Chimeric viral vector comprising heterologous viral elements for production of another viral vector
C12N 2710/10351
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10351Methods of production or purification of viral material
C12N 2800/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2800Nucleic acids vectors
40Systems of functionally co-operating vectors
Applicants
  • ENSOMA, INC. [US]/[US]
Inventors
  • ROY, Soumitra
Agents
  • SHORE, David, E.
  • ADAMS, Melissa, M.
  • ADATO, Ronen
  • BOUZA, Alexandra, A.
  • BUTEAU, Kristen, C.
  • BYCHOWSKI, Meaghan, E.
  • D'AMATO, Erica, M.
  • DAUKSS, Dana, M.
  • FLYNN, Peter, A.
  • GONCHAROFF, Dustin, K.
  • HAULBROOK, William, R.
  • HERSCHBACH JARRELL, Brenda
  • HINRICHSEN, Michael
  • KAUR, Mandeep
  • KITTO, Rebekah, Z.
  • KLEIN, Daniel, A.
  • LI, Xiaodong
  • LYON, Charles, E.
  • MA, Longle
  • MEDINA, Rolando
  • MONROE, Margo, R.
  • PACE, Nicholas, J.
  • POLIO, Samuel, R.
  • REARICK, John, P.
  • REESE, Brian, E.
  • SCHMITT, Michael
  • SCHONEWALD, Stephanie, L.
  • SHINALL, Michael, A.
  • SUBRAMANIAN, Sowmya
  • TSE, Janet, M.
  • VETTER, Michael, L.
  • VRABLIK, Tracy, L.
Priority Data
63/129,34622.12.2020US
63/215,36025.06.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ADENOVIRAL SEROTYPE 35 HELPER VECTORS
(FR) VECTEURS ADÉNOVIRAUX DE SÉROTYPE 35 AUXILIAIRES
Abstract
(EN) The present disclosure provides, among other things, Ad35 helper genomes and vectors useful in gene therapy, e.g., for production of helper-dependent Ad35 donor vectors. Helper genomes of the present disclosure include a conditionally defective packaging sequence.
(FR) La présente divulgation concerne, entre autres, des génomes auxiliaires d'Ad35 et des vecteurs utiles en thérapie génique, par exemple pour la production de vecteurs donneurs d'Ad35 dépendants d'un virus auxiliaire. Les génomes auxiliaires de la présente divulgation comprennent une séquence d'encapsidation conditionnellement défectueuse.
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