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1. WO2022135425 - ATTENUATED VIRUS OF FLAVIVIRUS VIRUS AND USE THEREOF

Publication Number WO/2022/135425
Publication Date 30.06.2022
International Application No. PCT/CN2021/140236
International Filing Date 21.12.2021
IPC
C12N 7/01 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
C12N 7/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C12R 1/93 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
92Viruses
93Animal viruses
CPC
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C12N 2770/24121
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24121Viruses as such, e.g. new isolates, mutants or their genomic sequences
C12N 2770/24134
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N 2770/24152
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24151Methods of production or purification of viral material
24152relating to complementing cells and packaging systems for producing virus or viral particles
Applicants
  • 北京舜雷科技有限公司 BEIJING SHUNLEI BIOTECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 张波 ZHANG, Bo
  • 叶寒青 YE, Hanqing
  • 张亚南 ZHANG, Yanan
  • 李娜 LI, Na
  • 张秋艳 ZHANG, Qiuyan
  • 邓成林 DENG, Chenglin
  • 袁绍鹏 YUAN, Shaopeng
  • 占顺利 ZHAN, Shunli
  • 高磊 GAO, Lei
Agents
  • 北京植德律师事务所 MERITS & TREE
Priority Data
202011528256.122.12.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ATTENUATED VIRUS OF FLAVIVIRUS VIRUS AND USE THEREOF
(FR) VIRUS ATTÉNUÉ DU VIRUS DE FLAVIVIRUS ET SON UTILISATION
(ZH) 一种黄病毒属病毒的减毒病毒及其用途
Abstract
(EN) Provided are an attenuated virus of a flavivirus virus and the use thereof. The attenuated virus comprises a polyadenylic acid (poly(A)) sequence, wherein the polyadenylic acid (poly(A)) is used for replacing a part of the nucleotide sequence of a 3' untranslated region (3'UTR) of the flavivirus virus, so that the 3' untranslated region (3'UTR) of the attenuated virus obtained after the part of the nucleotide sequence of the flavivirus virus is replaced at least retains a 3'-end stem loop region (3'SL). The attenuated virus can be used for preparing safe and effective attenuated vaccine strains.
(FR) La présente invention concerne un virus atténué d'un virus de flavivirus et son utilisation. Le virus atténué comprend une séquence d'acide polyadénylique (poly(A)), l'acide polyadénylique (poly(A)) étant utilisé pour remplacer une partie de la séquence nucléotidique d'une région non traduite 3' (3'UTR) du virus flavivirus, de sorte que la région non traduite 3' (3'UTR) du virus atténué obtenue après le remplacement de la partie de la séquence nucléotidique du virus flavivirus conserve au moins une région de tige-boucle d'extrémité 3' (3'SL). Le virus atténué peut être utilisé pour préparer des souches de vaccin atténuées sûres et efficaces.
(ZH) 提供了一种黄病毒属病毒的减毒病毒及其用途,该减毒病毒包含多聚腺苷酸(poly(A))序列,该多聚腺苷酸(poly(A))序列用于替换该黄病毒属病毒的3'非翻译区(3'UTR)的部分核苷酸序列,使得该黄病毒属病毒被替换部分核苷酸序列后所获得的减毒病毒的3'非翻译区(3'UTR)至少保留3'端茎环区(3'SL)。该减毒病毒可以用于制备安全、有效的减毒疫苗株。
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