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A portable surgical system including a transparent and flexible plastic enclosure is disclosed. The enclosure is attached reversibly to the patient's body encompassing the surgical site such as to isolate and regulate the immediate environment of the surgical site, and to reduce bodily fluid splatters from the surgical site to the surgical providers. The enclosure includes an environmental control system configured to actively monitor and control the environment inside the enclosure such as to create and maintain essentially sterile conditions. The surgical systems can be used both for surgeries on a torso of a patient and on surgeries on arms or legs. The portable surgical system is lightweight and portable and can be used in con-ventional operating rooms to improve sterility, or in other circum-stances where no operating room is available, such as field hospitals and for on the field surgeries.