Processing

Please wait...

Settings

Settings

Goto Application

1. WO2021198706 - CORONAVIRUS VACCINES

Publication Number WO/2021/198706
Publication Date 07.10.2021
International Application No. PCT/GB2021/050830
International Filing Date 01.04.2021
IPC
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C12N 2770/20034
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
20011Coronaviridae
20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applicants
  • DIOSYNVAX LTD [GB]/[GB]
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE [GB]/[GB]
Inventors
  • HEENEY, Jonathan, Luke
  • VISHWANATH, Sneha
  • CARNELL, George
  • WELLS, David
  • FERRARI, Matteo
Agents
  • REDDIE & GROSE LLP
Priority Data
2004826.001.04.2020GB
2010672.010.07.2020GB
2015775.605.10.2020GB
2101824.710.02.2021GB
2103214.908.03.2021GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CORONAVIRUS VACCINES
(FR) VACCINS CONTRE LE CORONAVIRUS
Abstract
(EN) Designed coronavirus polypeptide sequences are described, and their use as vaccines against viruses of the coronavirus family. The designed sequences include designed coronavirus spike (S) proteins and fragments thereof, including designed S protein receptor binding domain (RBD) sequence SEQ ID NO:17, designed truncated S protein sequence SEQ ID NO:15, and designed full lenth S protein sequence SEQ ID NO:13. Designed coronavirus envelope (E), membrane (M), and nucleocapsid (N) protein sequences are also described, and their use as vaccines. Nucleic acid molecules encoding the polypeptides, vectors, fusion proteins, pharmaceutical compositions, cells, and their use as vaccines against viruses of the coronavirus family are also described.
(FR) L'invention concerne des séquences polypeptidiques de coronavirus conçues, et leur utilisation en tant que vaccins contre des virus de la famille des coronavirus. Les séquences conçues comprennent des protéines de spicule (S) de coronavirus conçues et des fragments de celles-ci, comprenant une séquence de domaine de liaison de récepteur (RBD) de protéine S conçue SEQ ID NO : 17, une séquence de protéine S tronquée conçue SEQ ID NO : 15, et une séquence de protéine S de longueur totale conçue SEQ ID NO : 13. L'invention concerne également des séquences de protéine conçues d'enveloppe de coronavirus (E), de membrane (M) et de nucléocapside (N), et leur utilisation en tant que vaccins. L'invention concerne également des molécules d'acide nucléique codant pour les polypeptides, des vecteurs, des protéines de fusion, des compositions pharmaceutiques, des cellules et leur utilisation en tant que vaccins contre des virus de la famille des coronavirus.
Latest bibliographic data on file with the International Bureau