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1. WO2022135563 - METHOD FOR SIMULTANEOUSLY INDUCING IMMUNE RESPONSE AGAINST MULTIPLE VIRUSES

Publication Number WO/2022/135563
Publication Date 30.06.2022
International Application No. PCT/CN2021/141198
International Filing Date 24.12.2021
IPC
C07K 14/11 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
11Orthomyxoviridae, e.g. influenza virus
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 15/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C12N 15/63 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A61K 39/145 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
CPC
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
Applicants
  • 上海市公共卫生临床中心 SHANGHAI PUBLIC HEALTH CLINICAL CENTER [CN]/[CN]
Inventors
  • 徐建青 XU, Jianqing
  • 张晓燕 ZHANG, Xiaoyan
  • 周东明 ZHOU, Dongming
  • 曹康丽 CAO, Kangli
  • 王祥 WANG, Xiang
  • 胡杨洋 HU, Yangyang
  • 丁龙飞 DING, Longfei
Agents
  • 上海专利商标事务所有限公司 SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC
Priority Data
202011552054.024.12.2020CN
PCT/CN2020/13902624.12.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR SIMULTANEOUSLY INDUCING IMMUNE RESPONSE AGAINST MULTIPLE VIRUSES
(FR) PROCÉDÉ POUR INDUIRE SIMULTANÉMENT UNE RÉPONSE IMMUNITAIRE CONTRE DE MULTIPLES VIRUS
(ZH) 同时诱导抗多种病毒的免疫应答的方法
Abstract
(EN) Provided is a method for simultaneously inducing an immune response against multiple viruses (such as influenza viruses and novel coronavirus). Provided is an immunogenic peptide including: (a) an immunogenic stem including an HA2 region of influenza virus hemagglutinin HA; (b) an immunogenic crown including a viral membrane protein or an immunogenic fragment thereof; and (c) optionally, other portions fused to the above-mentioned portions, wherein the virus from which the viral membrane protein is derived is different from the virus from which the HA2 region in (a) is derived.
(FR) L'invention concerne un procédé pour induire simultanément une réponse immunitaire contre de multiples virus (tels que des virus de la grippe et le nouveau coronavirus). L'invention concerne un peptide immunogène comprenant : (a) Une souche immunogène comprenant une région HA2 de l'hémagglutinine HA du virus de la grippe; (b) une couronne immunogène comprenant une protéine de membrane virale ou un fragment immunogène de celle-ci; et (c) éventuellement, d'autres parties fusionnées aux parties mentionnées ci-dessus, le virus à partir duquel la protéine de membrane virale est dérivée étant différent du virus à partir duquel la région HA2 dans (a) est dérivée.
(ZH) 提供同时诱导抗多种病毒(例如流感病毒以及新冠病毒)的免疫应答的方法。提供了一种免疫原性肽,其包含(a)免疫原茎部:其包含流感病毒血凝素HA的HA2区域;(b)免疫原冠部:其包含病毒膜蛋白或其免疫原性片段,其中所述病毒膜蛋白的来源病毒不同于(a)中HA2区域的来源病毒;以及(c)可任选地,与前述部分融合的其他部分。
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