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1. WO2022200333 - METHOD TO SELECTIVELY PERMEABILIZE AND/OR FRAGMENTIZE CELLS

Publication Number WO/2022/200333
Publication Date 29.09.2022
International Application No. PCT/EP2022/057464
International Filing Date 22.03.2022
IPC
A61B 18/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
C12M 1/42 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
CPC
A61B 18/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
18by applying electromagnetic radiation, e.g. microwaves
20using laser
A61B 2018/00577
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
00571for achieving a particular surgical effect
00577Ablation
A61F 2009/00872
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
007Methods or devices for eye surgery
008using laser
00861adapted for treatment at a particular location
00872Cornea
A61F 9/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
007Methods or devices for eye surgery
008using laser
C12M 35/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
35Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
02Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
C12M 45/07
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
45Means for pre-treatment of biological substances
07by electrical or electromagnetic forces
Applicants
  • UNIVERSITEIT GENT [BE]/[BE]
Inventors
  • BRAECKMANS, Kevin
  • DE SMEDT, Stefaan
  • SAUVAGE, Félix
  • HARIZAJ, Aranit
  • XIONG, Ranhua
Priority Data
21164292.123.03.2021EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD TO SELECTIVELY PERMEABILIZE AND/OR FRAGMENTIZE CELLS
(FR) PROCÉDÉ POUR PERMÉABILISER ET/OU FRAGMENTER SÉLECTIVEMENT DES CELLULES
Abstract
(EN) The invention relates to a method to selectively permeabilize and/or fragmentize cells. A structure comprising a material and particles able to absorb electromagnetic radiation and cells are brought at close distance from each other. Part of the particles embedded in the structure are exposed to the free surface of the structure. The structure and in particular the particles in the structure are 5 irradiated with electromagnetic radiation to selectively permeabilize and/or fragmentize the cells. Furthermore the invention relates to a structure for use in a photothermal process to selectively permeabilize and/or fragmentize cells.
(FR) L'invention concerne un procédé pour perméabiliser et/ou fragmenter sélectivement des cellules. Une structure comprenant un matériau et des particules aptes à absorber un rayonnement électromagnétique et des cellules sont rapprochées l'une de l'autre. Une partie des particules incorporées dans la structure est exposée à la surface libre de la structure. La structure et en particulier les particules dans la structure sont irradiées par un rayonnement électromagnétique pour perméabiliser et/ou fragmenter sélectivement les cellules. En outre, l'invention concerne une structure destinée à être utilisée dans un procédé photothermique pour perméabiliser et/ou fragmenter sélectivement des cellules.
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