Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022133970 - COMPOSITION COMPRISING ONCOLYTIC VIRUS AND APPLICATION THEREOF IN TUMOR TREATMENT

Publication Number WO/2022/133970
Publication Date 30.06.2022
International Application No. PCT/CN2020/139196
International Filing Date 25.12.2020
IPC
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 35/763 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61K 31/7105 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
C12N 15/113 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 35/763
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
Applicants
  • 苏州系统医学研究所 SUZHOU INSTITUTE OF SYSTEMS MEDICINE [CN]/[CN]
Inventors
  • 杨衡 YANG, Heng
  • 潘超虎 PAN, Chaohu
  • 李利利 LI, Lili
  • 李晓蓉 LI, Xiaorong
  • 陈羽 CHEN, Yu
Agents
  • 北京林达刘知识产权代理事务所(普通合伙) LINDA LIU & PARTNERS
Priority Data
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOSITION COMPRISING ONCOLYTIC VIRUS AND APPLICATION THEREOF IN TUMOR TREATMENT
(FR) COMPOSITION COMPRENANT UN VIRUS ONCOLYTIQUE ET SON APPLICATION DANS LE TRAITEMENT DE TUMEURS
(ZH) 一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用
Abstract
(EN) Provided is a composition comprising an oncolytic virus and an application thereof in tumor treatment. Specifically, provided are a composition comprising an oncolytic virus, an application of the composition in the preparation of a drug for killing dysplastic cells, inducing and promoting anti-tumor immune responses or eliminating immunosuppression in a tumor tissue microenvironment, an application in the preparation of a drug for treating a patient suffering from a tumor, and a method for slow and sustained killing of dysplastic cells. The composition comprising an oncolytic virus can reduce or eliminate the expression level of the BACH1 gene, thereby promoting the immunogenicity produced by the oncolytic virus, promoting the infiltration of T lymphocytes, increasing anti-tumor immune responses, and inhibiting tumor growth.
(FR) L'invention concerne une composition comprenant un virus oncolytique et son application dans le traitement de tumeurs. En particulier, l'invention concerne une composition comprenant un virus oncolytique, une application de la composition dans la préparation d'un médicament destiné à tuer des cellules dysplasiques, à induire et à favoriser des réponses immunitaires antitumorales ou à supprimer l'immunodépression dans un micro-environnement de tissu tumoral, une application dans la préparation d'un médicament destiné au traitement d'un patient souffrant d'une tumeur, et un procédé de destruction lente et prolongée de cellules dysplasiques. La composition comprenant un virus oncolytique peut réduire ou supprimer le niveau d'expression du gène BACH1, ce qui permet de favoriser l'immunogénicité produite par le virus oncolytique, de favoriser l'infiltration de lymphocytes T, d'augmenter les réponses immunitaires antitumorales et d'inhiber la croissance tumorale.
(ZH) 提供了一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用,具体来说,提供了一种包含溶瘤病毒的组合物,组合物在制备用于杀死异常增生性细胞、诱导促进抗肿瘤免疫反应或消除肿瘤组织微环境免疫抑制的药物中的应用,在制备治疗患有肿瘤的患者的药物中的应用以及缓慢持续杀伤异常增生性细胞的方法。所述包含溶瘤病毒的组合物能够降低或消除BACH1基因的表达水平,从而促进溶瘤病毒所产生的免疫原性、促进T淋巴细胞浸润,增加抗肿瘤免疫反应,抑制肿瘤生长。
Latest bibliographic data on file with the International Bureau