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1. WO2022140467 - TOPICAL COMPOSITIONS AND METHODS OF TREATING SKIN DISEASES AND CONDITIONS WITH SUCH COMPOSITIONS

Publication Number WO/2022/140467
Publication Date 30.06.2022
International Application No. PCT/US2021/064729
International Filing Date 21.12.2021
IPC
A61K 31/192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/327 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxy acids
A61K 9/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
CPC
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61K 31/327
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
Applicants
  • SAMSON PHARMA, LLC [US]/[US]
Inventors
  • DURRANI, Manzer J.
  • VALIA, Kirti H.
  • DURRANI, Samedyar
  • KAPLAN, David
Agents
  • WAACK, Janelle D.
Priority Data
63/128,21021.12.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TOPICAL COMPOSITIONS AND METHODS OF TREATING SKIN DISEASES AND CONDITIONS WITH SUCH COMPOSITIONS
(FR) COMPOSITIONS TOPIQUES ET PROCÉDÉS DE TRAITEMENT DE MALADIES ET D'ÉTATS CUTANÉS AVEC DE TELLES COMPOSITIONS
Abstract
(EN) A pharmaceutical composition is provided including tamibarotene or a salt or analog thereof, a solubilizer, a permeation enhancer, a polymeric emulsifier, and a surfactant. In a further preferred embodiment, the pharmaceutical composition is in the form of a gel or cream, and provides a smooth composition to apply to the skin. The invention is further directed to methods of manufacturing the pharmaceutical composition and methods of treating a patient's skin with the pharmaceutical composition.
(FR) L'invention concerne une composition pharmaceutique comprenant du tamibarotène ou un sel ou analogue de celui-ci, un solubilisant, un facilitateur de perméation, un émulsifiant polymère et un tensioactif. Dans un autre mode de réalisation préféré, la composition pharmaceutique se présente sous la forme d'un gel ou d'une crème, et fournit une composition lisse à appliquer sur la peau. L'invention concerne en outre des procédés de fabrication de la composition pharmaceutique et des procédés de traitement de la peau d'un patient avec la composition pharmaceutique.
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