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1. WO2022076611 - NOVEL REDOX-BASED THERAPEUTIC APPROACH FOR TREATMENT OF CANCER

Publication Number WO/2022/076611
Publication Date 14.04.2022
International Application No. PCT/US2021/053846
International Filing Date 06.10.2021
IPC
A61K 31/4166 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4166having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 233/86 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
86Oxygen and sulfur atoms, e.g. thiohydantoin
CPC
A61K 31/095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
095Sulfur, selenium, or tellurium compounds, e.g. thiols
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/132
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
132having two or more amino groups, e.g. spermidine, putrescine
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 33/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
04Sulfur, selenium or tellurium; Compounds thereof
Applicants
  • THE PENN STATE RESEARCH FOUNDATION [US]/[US]
Inventors
  • MISRA, Sougat
Agents
  • ZUCCHERO, Anthony J.
  • LANIER, J. Gibson
  • CALDERON MOLINA, Angie Dayan
Priority Data
63/088,15706.10.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL REDOX-BASED THERAPEUTIC APPROACH FOR TREATMENT OF CANCER
(FR) NOUVELLE APPROCHE THÉRAPEUTIQUE BASÉE SUR L'OXYDO-RÉDUCTION POUR LE TRAITEMENT DU CANCER
Abstract
(EN) Disclosed herein are compositions and methods for increasing the expression of human SLC7A11. The compositions include a combination of compounds that exhibit anti-proliferative activity against cancer cells. The compositions and methods can be used to treat a subject with cancer. Disclosed are also compositions and methods of treating a coronavirus infection, Zika virus, influenza virus infection, human immunodeficiency virus (HIV), or Rhinovirus.
(FR) L'invention concerne des compositions et des méthodes pour augmenter l'expression de SLC7A11 humain. Les compositions comprennent une combinaison de composés qui présentent une activité anti-proliférative contre des cellules cancéreuses. Les compositions et les méthodes peuvent être utilisées pour traiter un sujet atteint d'un cancer. L'invention concerne également des compositions et des méthodes de traitement d'une infection à coronavirus, d'un virus Zika, d'une infection par le virus de la grippe, d'un virus de l'immunodéficience humaine (VIH) ou d'un rhinovirus.
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